Dynamic Aspects of Presynaptic Calcium Currents Mediating Synaptic Transmission

Overview

Journal Cell Calcium

Publisher Elsevier

Specialties Cell Biology
Endocrinology

Date 2005 Apr 12

PMID 15820400

Citations 8

Authors

Tomoyuki Takahashi

Affiliations

Soon will be listed here.

Abstract

Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch of their alpha1 subunits. Dynamic changes of presynaptic VGCCs alter synaptic efficacy, thereby contributing to a variety of modulations of the CNS function.

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