Alcohol Drinking and Colorectal Cancer: a Population-based Prospective Cohort Study in China

Overview

Journal Eur J Epidemiol

Specialty Public Health

Date 2005 Mar 29

PMID 15792281

Citations 11

Authors

Kun Chen

Qinting Jiang

Xinyuan Ma

Qilong Li

Kaiyan Yao

Weiping Yu

Shu Zheng

Affiliations

Soon will be listed here.

Abstract

Study Objective: To asses the association between alcohol consumption and the risk of colorectal cancer (CRC) in the Chinese population.

Design: A population-based prospective cohort study was initiated from the colorectal cancer screening population in Jiashan County in 1989-1990. The drinking habits of individuals were investigated with demographic information.

Setting: A cohort study was followed-up from 1st May 1990 to 1st January 2001 and censored at the date of diagnosis of CRC, at death from any causes, or at 1st January 2001, whichever came first, and the person-time was computed.

Participants: Two hundred and forty two CRC patients were diagnosed during the study period and 64,100 individuals finished the follow-up.

Results: The distribution of sex, smoking status, occupation, education level and marital status were all significantly different among different drinking habits at baseline. When the above factors were adjusted, no significant association was observed between alcohol consumption and the risk of CRC. Exclusion of individuals diagnosed cancer less than 1 year after the examination date did not alter the strength of an alcohol-CRC relationship. Further analysis in sex strata also did not show a significant relationship.

Conclusions: Alcohol drinking may not be associated with a higher risk of CRC in the Chinese population.

Citing Articles

Alcohol consumption and colorectal cancer risk: A mendelian randomization study.

Li Y, Ye D, Zhou W, Liu B, Mao Y, Sun X Front Genet. 2022; 13:967229.

PMID: 36212149 PMC: 9540194. DOI: 10.3389/fgene.2022.967229.

Colorectal cancer in the Linxian China Nutrition Intervention Trial: Risk factors and intervention results.

Keskin H, Wang S, Etemadi A, Fan J, Dawsey S, Abnet C PLoS One. 2021; 16(9):e0255322.

PMID: 34525122 PMC: 8443060. DOI: 10.1371/journal.pone.0255322.

Alcohol drinking and risks of total and site-specific cancers in China: A 10-year prospective study of 0.5 million adults.

Im P, Millwood I, Kartsonaki C, Chen Y, Guo Y, Du H Int J Cancer. 2021; 149(3):522-534.

PMID: 33634874 PMC: 8359462. DOI: 10.1002/ijc.33538.

Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies.

Choi Y, Myung S, Lee J Cancer Res Treat. 2017; 50(2):474-487.

PMID: 28546524 PMC: 5912140. DOI: 10.4143/crt.2017.094.

A critical analysis of the relationship between aldehyde dehydrogenases-2 Glu487Lys polymorphism and colorectal cancer susceptibility.

Chen B, Hu K, Zhang J, Wei Z, Meng X, Xiong M Pathol Oncol Res. 2015; 21(3):727-33.

PMID: 25573590 DOI: 10.1007/s12253-014-9881-8.

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