Relationship of Airway Wall Thickening to an Imbalance Between Matrix Metalloproteinase-9 and Its Inhibitor in Asthma

Overview

Journal Thorax

Date 2005 Mar 26

PMID 15790981

Citations 29

Authors

H Matsumoto

A Niimi

M Takemura

T Ueda

M Minakuchi

R Tabuena

K Chin

T Mio

Y Ito

S Muro

T Hirai

S Morita

S Fukuhara

M Mishima

Affiliations

Soon will be listed here.

Abstract

Background: The balance between matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) may be critical in extracellular matrix remodelling, a characteristic of asthmatic airways. An excess of TIMP-1 over MMP-9 has been associated with chronic airflow obstruction but the mechanisms underlying this association remain unknown. Recent computed tomographic (CT) studies indicate that airway wall thickening is associated with chronic airflow obstruction.

Methods: Sputum levels of MMP-9, TIMP-1, and their molar ratio were examined in 26 patients with stable asthma and their relationship with pulmonary function and airway wall thickness, assessed by a validated CT technique which measured wall area corrected by body surface area (WA/BSA), the ratio of WA to outer wall area (WA%), and the absolute wall thickness corrected by radicalBSA of a segmental bronchus (T/ radicalBSA), was examined.

Results: Sputum MMP-9 levels were inversely correlated with WA% and TIMP-1 levels were positively correlated with WA/BSA and T/ radicalBSA. The MMP-9/TIMP-1 molar ratio was inversely correlated with WA% and T/ radicalBSA and positively correlated with post-bronchodilator values of mid-forced expiratory flow and maximum expiratory flow at the quartile of lung volume.

Conclusion: Excess TIMP-1 may have a pathogenetic role in airway wall thickening in asthmatic patients which may result in chronic airflow obstruction.

Citing Articles

Food Allergy Genetics and Epigenetics: A Review of Genome-Wide Association Studies.

Arnau-Soler A, Tremblay B, Sun Y, Madore A, Simard M, Kersten E Allergy. 2024; 80(1):106-131.

PMID: 39698764 PMC: 11724255. DOI: 10.1111/all.16429.

IL-6 and TIMP-1 Correlated to Airway Pathogen Colonization and Predict Disease Severity in Patients with Non-Cystic Fibrosis Bronchiectasis.

Lin H, Hsieh M, Lo Y, Huang H, Huang S, Huang C J Inflamm Res. 2024; 17:5701-5709.

PMID: 39219819 PMC: 11366244. DOI: 10.2147/JIR.S465413.

Roles of Tissue Inhibitor of Metalloproteinase-1 in Severe Asthma.

Kim S Allergy Asthma Immunol Res. 2023; 15(4):416-418.

PMID: 37469240 PMC: 10359650. DOI: 10.4168/aair.2023.15.4.416.

Pathogens and Pathogenesis in Wheezing Diseases in Children Under 6.

Tang Y, Yang Y, He R, Huang R, Zheng X, Liu C Front Oncol. 2022; 12:922214.

PMID: 35912246 PMC: 9329614. DOI: 10.3389/fonc.2022.922214.

The effects of nebulized ketamine and intravenous magnesium sulfate on corticosteroid resistant asthma exacerbation; a randomized clinical trial.

Farshadfar K, Sohooli M, Shekouhi R, Taherinya A, Qorbani M, Rezaei-Kojani M Asthma Res Pract. 2021; 7(1):15.

PMID: 34847965 PMC: 8630847. DOI: 10.1186/s40733-021-00081-1.

References

Kasahara K, Shiba K, Ozawa T, Okuda K, Adachi M . Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma. Thorax. 2002; 57(3):242-6. PMC: 1746264. DOI: 10.1136/thorax.57.3.242. View

Jeffery P . Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med. 2001; 164(10 Pt 2):S28-38. DOI: 10.1164/ajrccm.164.supplement_2.2106061. View

James A, Maxwell P, Elliot J, Carroll N . The relationship of reticular basement membrane thickness to airway wall remodeling in asthma. Am J Respir Crit Care Med. 2002; 166(12 Pt 1):1590-5. DOI: 10.1164/rccm.2108069. View

Corbel M, Caulet-Maugendre S, Germain N, Lagente V, Boichot E . Enhancement of gelatinase activity during development of subepithelial fibrosis in a murine model of asthma. Clin Exp Allergy. 2003; 33(5):696-704. DOI: 10.1046/j.1365-2222.2003.01581.x. View

Wenzel S, Balzar S, Cundall M, Chu H . Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol. 2003; 111(6):1345-52. DOI: 10.1067/mai.2003.1464. View

McParland B, Macklem P, Pare P . Airway wall remodeling: friend or foe?. J Appl Physiol (1985). 2003; 95(1):426-34. DOI: 10.1152/japplphysiol.00159.2003. View

Oshita Y, Koga T, Kamimura T, Matsuo K, Rikimaru T, Aizawa H . Increased circulating 92 kDa matrix metalloproteinase (MMP-9) activity in exacerbations of asthma. Thorax. 2003; 58(9):757-60. PMC: 1746799. DOI: 10.1136/thorax.58.9.757. View

Cundall M, Sun Y, Miranda C, Trudeau J, Barnes S, Wenzel S . Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids. J Allergy Clin Immunol. 2003; 112(6):1064-71. DOI: 10.1016/j.jaci.2003.08.013. View

Takemura M, Niimi A, Minakuchi M, Matsumoto H, Ueda T, Chin K . Bronchial dilatation in asthma: relation to clinical and sputum indices. Chest. 2004; 125(4):1352-8. DOI: 10.1378/chest.125.4.1352. View

10.

Niimi A, Matsumoto H, Amitani R, Nakano Y, Sakai H, Takemura M . Effect of short-term treatment with inhaled corticosteroid on airway wall thickening in asthma. Am J Med. 2004; 116(11):725-31. DOI: 10.1016/j.amjmed.2003.11.026. View

11.

Roth M, Johnson P, Borger P, Bihl M, Rudiger J, King G . Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. N Engl J Med. 2004; 351(6):560-74. DOI: 10.1056/NEJMoa021660. View

12.

Takishima T, Hida W, Sasaki H, Suzuki S, Sasaki T . Direct-writing recorder of the dose-response curves of the airway to methacholine. Clinical application. Chest. 1981; 80(5):600-6. DOI: 10.1378/chest.80.5.600. View

13.

Woessner Jr J . Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 1991; 5(8):2145-54. View

14.

Pin I, Gibson P, Kolendowicz R, Girgis-Gabardo A, Denburg J, Hargreave F . Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax. 1992; 47(1):25-9. PMC: 463545. DOI: 10.1136/thx.47.1.25. View

15.

Hayakawa T . Tissue inhibitors of metalloproteinases and their cell growth-promoting activity. Cell Struct Funct. 1994; 19(3):109-14. DOI: 10.1247/csf.19.109. View

16.

Kikuchi K, Kubo M, Sato S, Fujimoto M, Tamaki K . Serum tissue inhibitor of metalloproteinases in patients with systemic sclerosis. J Am Acad Dermatol. 1995; 33(6):973-8. DOI: 10.1016/0190-9622(95)90289-9. View

17.

Gruber B, Sorbi D, French D, Marchese M, Nuovo G, Kew R . Markedly elevated serum MMP-9 (gelatinase B) levels in rheumatoid arthritis: a potentially useful laboratory marker. Clin Immunol Immunopathol. 1996; 78(2):161-71. DOI: 10.1006/clin.1996.0025. View

18.

Ohno I, Ohtani H, Nitta Y, Suzuki J, Hoshi H, Honma M . Eosinophils as a source of matrix metalloproteinase-9 in asthmatic airway inflammation. Am J Respir Cell Mol Biol. 1997; 16(3):212-9. DOI: 10.1165/ajrcmb.16.3.9070604. View

19.

Okada S, Kita H, George T, Gleich G, Leiferman K . Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. Am J Respir Cell Mol Biol. 1997; 17(4):519-28. DOI: 10.1165/ajrcmb.17.4.2877. View

20.

Mautino G, Oliver N, Chanez P, Bousquet J, Capony F . Increased release of matrix metalloproteinase-9 in bronchoalveolar lavage fluid and by alveolar macrophages of asthmatics. Am J Respir Cell Mol Biol. 1997; 17(5):583-91. DOI: 10.1165/ajrcmb.17.5.2562. View