Identification of Hippocampus-related Candidate Genes for Alzheimer's Disease

Overview

Journal Ann Neurol

Specialty Neurology

Date 2005 Mar 24

PMID 15786443

Citations 23

Authors

Keiko Taguchi

Hidehisa D Yamagata

Wangtao Zhong

Kouzin Kamino

Hiroyasu Akatsu

Ryuji Hata

Takayuki Yamamoto

Kenji Kosaka

Masatoshi Takeda

Ikuko Kondo

Tetsuro Miki

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.

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