Genotyping over 100,000 SNPs on a Pair of Oligonucleotide Arrays

Overview

Journal Nat Methods

Specialties Biomedical Engineering
Pathology

Date 2005 Mar 23

PMID 15782172

Citations 146

Authors

Hajime Matsuzaki

Shoulian Dong

Halina Loi

Xiaojun Di

Guoying Liu

Earl Hubbell

Jane Law

Tam Berntsen

Monica Chadha

Henry Hui

Geoffrey Yang

Giulia C Kennedy

Teresa A Webster

Simon Cawley

P Sean Walsh

Keith W Jones

Stephen P A Fodor

Rui Mei

Affiliations

Soon will be listed here.

Abstract

We present a genotyping method for simultaneously scoring 116,204 SNPs using oligonucleotide arrays. At call rates >99%, reproducibility is >99.97% and accuracy, as measured by inheritance in trios and concordance with the HapMap Project, is >99.7%. Average intermarker distance is 23.6 kb, and 92% of the genome is within 100 kb of a SNP marker. Average heterozygosity is 0.30, with 105,511 SNPs having minor allele frequencies >5%.

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