Calmodulin Kinase Signaling in Heart: an Intriguing Candidate Target for Therapy of Myocardial Dysfunction and Arrhythmias

Overview

Journal Pharmacol Ther

Specialty Pharmacology

Date 2005 Mar 23

PMID 15781121

Citations 51

Authors

Mark E Anderson

Affiliations

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Abstract

The multifunctional Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) has emerged as a proarrhythmic and procardiomyopathic signal in a wide range of structural heart diseases. This review discusses CaMKII structure and function and recent evidence implicating CaMKII inhibition as a potential strategy for treating myocardial dysfunction and arrhythmias in the setting of structural heart disease.

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