CD19 Function in Central and Peripheral B-cell Development

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2005 Mar 22

PMID 15778510

Citations 45

Authors

Christopher J Del Nagro

Dennis C Otero

Amy N Anzelon

Sidne A Omori

Ravi V Kolla

Robert C Rickert

Affiliations

Soon will be listed here.

Abstract

Although the B-cell antigen receptor (BCR) factors most prominently in the maintenance and differentiation of mature B cells, it is now appreciated that co-receptor molecules can positively or negatively modulate signals through the BCR. Co-receptors are functionally defined as modifiers of BCR engagement and signal transduction, and are distinct from other accessory molecules that act independently to regulate B-cell growth. The co-receptor CD19 functions to augment signals by the pre-BCR/BCR and in doing so can modulate B-cell fate decisions at multiple stages of development. In mature B cells, CD19 also associates with complement receptor 2 (CR2/CD21) and is pivotal for transducing signals induced by co-recognition of complement C3d-fixed antigens by the BCR and CD21. In this article, we focus on recent progress in the understanding of CD19 function through the characterization of mouse models that relate in vivo function to biochemical properties of CD19.

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