Human Immunodeficiency Virus-specific Responses in Adult Ugandans: Patterns of Cross-clade Recognition

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2005 Mar 16

PMID 15767414

Citations 9

Authors

Banson Barugahare

Chris Baker

Okumu KAluoch

Richard Donovan

Mohamed Elrefaei

Mark Eggena

Norman Jones

Steven Mutalya

Cissy Kityo

Peter Mugyenyi

Huyen Cao

Affiliations

Soon will be listed here.

Abstract

Human immunodeficiency virus (HIV) or AIDS is currently the leading cause of death in Uganda, with at least three HIV clades (subtypes) accounting for most new infections. Whether an effective vaccine formulated on viruses from a single clade will be able to protect against infection from other local clades remains unresolved. We examined the T-cell immune responses from a cohort of HIV-seropositive individuals in Uganda with predominantly clade A and D infections. Surprisingly, we observed similar frequencies of cross-clade T-cell responses to the gag, env, and nef regions. Our data suggest that the level of viral sequence variability between distinct HIV strains does not predict the degree of cross-clade responses. High sequence homologies were also observed between consensus peptides and sequences from viral isolates, supporting the use of consensus amino acid sequences to identify immunogenic regions in studies of large populations.

Citing Articles

Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection.

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Enrichment of HIV-1 subtype AD recombinants in a Ugandan cohort of severely septic patients.

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Clade-specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 clade A1 p24.

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Epitope mapping of HIV-specific CD8+ T cells in a cohort dominated by clade A1 infection.

McKinnon L, Mao X, Kimani J, Wachihi C, Semeniuk C, Mendoza M PLoS One. 2009; 4(9):e6965.

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The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda.

Ssewanyana I, Baker C, Ruel T, Bousheri S, Kamya M, Dorsey G AIDS Res Hum Retroviruses. 2009; 25(1):65-71.

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