How Many States Can the Motor Molecule, Prestin, Assume in an Electric Field?

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 2005 Mar 15

PMID 15764650

Citations 10

Authors

Marc P Scherer

Anthony W Gummer

Affiliations

Soon will be listed here.

Abstract

By using an analogy between the magnetization of a paramagnetic material in an external magnetic field and the electric polarization of the lateral wall of outer hair cells in response to the transmembrane potential, we show that, based on experimental data on the charge transfer across the membrane, it is impossible to make a statement about the number of possible conformational states of the motor molecule, prestin. Although the choice of model affects the values of derived parameters, such as total charge and motor charge, this is frequently overlooked in the literature.

Citing Articles

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Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5.

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Evidence that prestin has at least two voltage-dependent steps.

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Prestin surface expression and activity are augmented by interaction with MAP1S, a microtubule-associated protein.

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