Molecular Cloning and Serological Characterization of a New Plasmodium Vivax Recombinant Antigen Which Contains Apolipoprotein B-100 Like Sequences

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 1992 Apr 30

PMID 1575740

Citations 2

Authors

P Ray

Y D Sharma

Affiliations

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Abstract

We have isolated a new recombinant antigen 'PV12' of Plasmodium vivax by immunological screening of the genomic library. The antigen shows a sequence homology with human apolipoprotein B-100. A large number of P. vivax infected individuals (79%) were seropositive against this antigen. The probable function of this antigen could be to evade the host defence system (i) by inactivating the perforin of natural killer cells and (ii) by engaging the host immune system to produce antibodies against this decoy antigen.

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Sharma Y, Fakruddin J, Bhutani N, Kaushik R, Raina O, Sharma I Indian J Clin Biochem. 2012; 12(Suppl 1):49-51.

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Epitope reactions can be gauged by relative antibody discriminating specificity (RADS) values supported by deletion, substitution and cysteine bridge formation analyses: potential uses in pathogenesis studies.

Falconar A BMC Res Notes. 2012; 5:208.

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