The Structural Basis of Blebbistatin Inhibition and Specificity for Myosin II

Overview

Journal Nat Struct Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2005 Mar 8

PMID 15750603

Citations 163

Authors

John S Allingham

Robert Smith

Ivan Rayment

Affiliations

Soon will be listed here.

Abstract

Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.

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