The Epithelial Calcium Channels TRPV5 and TRPV6: Regulation and Implications for Disease

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 2005 Mar 5

PMID 15747113

Citations 28

Authors

Monique van Abel

Joost G J Hoenderop

Rene J M Bindels

Affiliations

Soon will be listed here.

Abstract

The epithelial Ca(2+) channels TRPV5 and TRPV6 represent a new family of Ca(2+) channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca(2+) entry mechanism in active Ca(2+) transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca(2+) (re)absorption makes it a prime target for regulation to maintain Ca(2+) balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca(2+) channels.

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