The CD14 C-159T Polymorphism is Not Associated with Asthma or Asthma Severity in an Australian Adult Population

Overview

Journal Thorax

Date 2005 Mar 3

PMID 15741437

Citations 13

Authors

M-A Kedda

F Lose

D Duffy

E Bell

P J Thompson

J Upham

Affiliations

Soon will be listed here.

Abstract

Background: CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to play a role in the polarisation of T lymphocytes into Th1 and Th2 subsets, thereby influencing the cytokine profile and subsequent IgE production in response to antigen/allergen contact in allergic phenotypes. A functional C-159T polymorphism has been described in the promoter region of the gene and has been associated with increased gene expression, atopy, and non-atopic asthma in different ethnic populations. A study was undertaken to examine the association between the C-159T polymorphism and asthma, asthma severity, and atopy in a large Australian white population.

Methods: PCR-RFLP analysis was used to characterise the C-159T polymorphism in mild (n = 264), moderate (n = 225) and severe (n = 79) asthmatic patients and non-asthmatic controls (n = 443), including atopic (n = 688) and non-atopic (n = 323) individuals. Association analyses were performed using chi(2) tests.

Results: There was no association between the polymorphism and asthma (p = 0.468) or asthma severity (p = 0.727), and only a very weak association with atopy (p = 0.084). A meta-analysis of all studies conducted to date revealed similar genotypic frequencies in white ethnic populations and confirmed that there was no overall association with atopy (p = 0.52) or asthma (p = 0.23), although there was significant between study heterogeneity (p = 0.01).

Conclusions: This study confirms that there is no association between the CD14 C-159T polymorphism and asthma or asthma severity and a weak association between this polymorphism and atopy in an adult population.

Citing Articles

Role of offending out-door aero-allergen and CD14 C(-159)T polymorphism in development and severity of asthma in a Kolkata patient population.

Dutta S, Mondal P, Saha N, Moitra S, Podder S, Ghosh A Afr Health Sci. 2018; 17(4):1101-1109.

PMID: 29937881 PMC: 5870296. DOI: 10.4314/ahs.v17i4.18.

Association of CD14 -159 (-260C/T) polymorphism and asthma risk: an updated genetic meta-analysis study.

Wang D, Yang Y, Xu J, Zhou Z, Yu H Medicine (Baltimore). 2016; 95(39):e4959.

PMID: 27684840 PMC: 5265933. DOI: 10.1097/MD.0000000000004959.

No Association Between -159C/T Polymorphism of the CD14 Gene and Asthma Risk: a Meta-Analysis of 36 Case-Control Studies.

Zhang R, Deng R, Li H, Chen H Inflammation. 2015; 39(1):457-466.

PMID: 26463530 DOI: 10.1007/s10753-015-0269-z.

Hesperidin inhibits inflammatory response induced by Aeromonas hydrophila infection and alters CD4+/CD8+ T cell ratio.

Abuelsaad A, Allam G, Al-Solumani A Mediators Inflamm. 2014; 2014:393217.

PMID: 24891765 PMC: 4033591. DOI: 10.1155/2014/393217.

CD14 -159C/T polymorphism contributes to the susceptibility to tuberculosis: evidence from pooled 1,700 cases and 1,816 controls.

Miao R, Ge H, Xu L, Xu F Mol Biol Rep. 2014; 41(5):3481-6.

PMID: 24519436 DOI: 10.1007/s11033-014-3210-x.

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