Acidocalcisomes - Conserved from Bacteria to Man

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2005 Mar 2

PMID 15738951

Citations 187

Authors

Roberto Docampo

Wanderley De Souza

Kildare Miranda

Peter Rohloff

Silvia N J Moreno

Affiliations

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Abstract

Recent work has shown that acidocalcisomes, which are electron-dense acidic organelles rich in calcium and polyphosphate, are the only organelles that have been conserved during evolution from prokaryotes to eukaryotes. Acidocalcisomes were first described in trypanosomatids and have been characterized in most detail in these species. Acidocalcisomes have been linked with several functions, including storage of cations and phosphorus, polyphosphate metabolism, calcium homeostasis, maintenance of intracellular pH homeostasis and osmoregulation. Here, we review acidocalcisome ultrastructure, composition and function in different trypanosomatids and other organisms.

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