Development of Conjugated Linoleic Acid (CLA)-mediated Lipoatrophic Syndrome in the Mouse

Overview

Journal Biochimie

Specialty Biochemistry

Date 2005 Mar 1

PMID 15733740

Citations 20

Authors

H Poirier

I Niot

L Clement

M Guerre-Millo

P Besnard

Affiliations

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Abstract

Conjugated linoleic acids (CLA) are positional and geometric dienoic isomers of linoleic acid. Dietary CLA supplementation leads to a drop in fat mass in various species, including in humans. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with severe hyperinsulinemia, insulin resistance and massive liver steatosis. The origin of these adverse side effects and putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.

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