Two-year Prospective Naturalistic Study of Remission from Major Depressive Disorder As a Function of Personality Disorder Comorbidity

Overview

Journal J Consult Clin Psychol

Specialty Psychology

Date 2005 Feb 16

PMID 15709834

Citations 39

Authors

Carlos M Grilo

Charles A Sanislow

M Tracie Shea

Andrew E Skodol

Robert L Stout

John G Gunderson

Shirley Yen

Donna S Bender

Maria E Pagano

Mary C Zanarini

Leslie C Morey

Thomas H McGlashan

Affiliations

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Abstract

In this study, the authors examined prospectively the 24-month natural course of remission from major depressive disorder (MDD) as a function of personality disorder (PD) comorbidity. In 302 participants (196 women, 106 men), psychiatric and PDs were assessed at baseline with diagnostic interviews, and the course of MDD was assessed with the Longitudinal Interval Follow-Up Evaluation at 6-, 12-, and 24-month follow-ups. Survival analyses revealed an overall 24-month remission rate of 73.5% for MDD that differed little by gender. Participants with MDD who had certain forms of coexisting PD psychopathology (schizotypal, borderline, or avoidant) as their primary PD diagnoses had a significantly longer time to remission from MDD than did patients with MDD without any PD. These PDs emerged as robust predictors of slowed remission from MDD even when controlling for other negative prognostic predictors.

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References

Zanarini M, Skodol A, Bender D, Dolan R, Sanislow C, Schaefer E . The Collaborative Longitudinal Personality Disorders Study: reliability of axis I and II diagnoses. J Pers Disord. 2001; 14(4):291-9. DOI: 10.1521/pedi.2000.14.4.291. View

Rothschild L, Zimmerman M . Borderline personality disorder and age of onset in major depression. J Pers Disord. 2002; 16(2):189-99. DOI: 10.1521/pedi.16.2.189.22551. View

Bender D, Dolan R, Skodol A, Sanislow C, Dyck I, McGlashan T . Treatment utilization by patients with personality disorders. Am J Psychiatry. 2001; 158(2):295-302. DOI: 10.1176/appi.ajp.158.2.295. View

Warshaw M, Dyck I, Allsworth J, Stout R, Keller M . Maintaining reliability in a long-term psychiatric study: an ongoing inter-rater reliability monitoring program using the longitudinal interval follow-up evaluation. J Psychiatr Res. 2001; 35(5):297-305. DOI: 10.1016/s0022-3956(01)00030-9. View

Hankin B, Abramson L . Development of gender differences in depression: an elaborated cognitive vulnerability-transactional stress theory. Psychol Bull. 2001; 127(6):773-96. DOI: 10.1037/0033-2909.127.6.773. View

Hart A, Craighead W, Craighead L . Predicting recurrence of major depressive disorder in young adults: a prospective study. J Abnorm Psychol. 2001; 110(4):633-43. DOI: 10.1037//0021-843x.110.4.633. View

Mulder R . Personality pathology and treatment outcome in major depression: a review. Am J Psychiatry. 2002; 159(3):359-71. DOI: 10.1176/appi.ajp.159.3.359. View

Mueller T, Leon A, Keller M, Solomon D, Endicott J, Coryell W . Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. Am J Psychiatry. 1999; 156(7):1000-6. DOI: 10.1176/ajp.156.7.1000. View

Grilo C, Anez L, McGlashan T . DSM-IV axis II comorbidity with borderline personality disorder in monolingual Hispanic psychiatric outpatients. J Nerv Ment Dis. 2002; 190(5):324-30. DOI: 10.1097/00005053-200205000-00009. View

10.

Grilo C, Sanislow C, Gunderson J, Pagano M, Yen S, Zanarini M . Two-year stability and change of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders. J Consult Clin Psychol. 2004; 72(5):767-75. PMC: 3289406. DOI: 10.1037/0022-006X.72.5.767. View

11.

Katz M, Secunda S, Hirschfeld R, Koslow S . NIMH clinical research branch collaborative program on the psychobiology of depression. Arch Gen Psychiatry. 1979; 36(7):765-71. DOI: 10.1001/archpsyc.1979.01780070043004. View

12.

Keller M, SHAPIRO R, Lavori P, Wolfe N . Recovery in major depressive disorder: analysis with the life table and regression models. Arch Gen Psychiatry. 1982; 39(8):905-10. DOI: 10.1001/archpsyc.1982.04290080025004. View

13.

Keller M, Lavori P, Lewis C, Klerman G . Predictors of relapse in major depressive disorder. JAMA. 1983; 250(24):3299-304. View

14.

Castaneda R, Franco H . Sex and ethnic distribution of borderline personality disorder in an inpatient sample. Am J Psychiatry. 1985; 142(10):1202-3. DOI: 10.1176/ajp.142.10.1202. View

15.

Angst J . The course of affective disorders. Psychopathology. 1986; 19 Suppl 2:47-52. DOI: 10.1159/000285131. View

16.

Keller M, Lavori P, Friedman B, Nielsen E, Endicott J, Andreasen N . The Longitudinal Interval Follow-up Evaluation. A comprehensive method for assessing outcome in prospective longitudinal studies. Arch Gen Psychiatry. 1987; 44(6):540-8. DOI: 10.1001/archpsyc.1987.01800180050009. View

17.

Widiger T, Frances A, Spitzer R, Williams J . The DSM-III-R personality disorders: an overview. Am J Psychiatry. 1988; 145(7):786-95. DOI: 10.1176/ajp.145.7.786. View

18.

Hyler S, Skodol A, Kellman H, Oldham J, Rosnick L . Validity of the Personality Diagnostic Questionnaire--revised: comparison with two structured interviews. Am J Psychiatry. 1990; 147(8):1043-8. DOI: 10.1176/ajp.147.8.1043. View

19.

Frank E, Prien R, Jarrett R, Keller M, Kupfer D, Lavori P . Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry. 1991; 48(9):851-5. DOI: 10.1001/archpsyc.1991.01810330075011. View

20.

Oldham J, Skodol A, Kellman H, Hyler S, Rosnick L, Davies M . Diagnosis of DSM-III-R personality disorders by two structured interviews: patterns of comorbidity. Am J Psychiatry. 1992; 149(2):213-20. DOI: 10.1176/ajp.149.2.213. View