Electrochemical Approach of Anticancer Drugs--DNA Interaction

Overview

Journal J Pharm Biomed Anal

Specialty Chemistry

Date 2005 Feb 15

PMID 15708659

Citations 18

Authors

S Rauf

J J Gooding

K Akhtar

M A Ghauri

M Rahman

M A Anwar

A M Khalid

Affiliations

Soon will be listed here.

Abstract

The interaction of drugs with DNA is among the most important aspects of biological studies in drug discovery and pharmaceutical development processes. In recent years there has been a growing interest in the electrochemical investigation of interaction between anticancer drugs and DNA. Observing the pre and post electrochemical signals of DNA or drug interaction provides good evidence for the interaction mechanism to be elucidated. Also this interaction could be used for the quantification of these drugs and for the determination of new drugs targeting DNA. Electrochemical approach can provide new insight into rational drug design and would lead to further understanding of the interaction mechanism between anticancer drugs and DNA.

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