The Mannose Receptor is Expressed by Subsets of APC in Non-lymphoid Organs

Overview

Journal BMC Immunol

Publisher Biomed Central

Specialty Allergy & Immunology

Date 2005 Feb 11

PMID 15701168

Citations 22

Authors

Sheena A Linehan

Affiliations

Soon will be listed here.

Abstract

Background: The mannose receptor (MR) is an endocytic receptor of Mphi and endothelial cell subsets whose natural ligands include both self glycoproteins and microbial glycans. It is also expressed by immature cultured dendritic cells (DC), where it mediates high efficiency uptake of glycosylated antigens, yet its role in antigen handling in vivo is unknown. Knowledge of which APC subsets express MR will assist the design of experiments to address its immunological functions. Here the expression of MR by MHC class II positive APC in non-lymphoid organs of the mouse is described.

Results: MR positive APC were identified in several peripheral organs: skin, liver, cardiac and skeletal muscle and tongue. MR positive cells in salivary gland, thyroid and pancreas coexpressed MHC class II and the myeloid markers macrosialin and sialoadhesin, but not the dendritic cell markers CD11c or DEC-205. MR and MHC class II colocalised in confocal microscope images, implying that antigen capture may be the primary role of MR in these cells. Distinct ligands of MR were found in salivary gland and pancreas tissue lysates that are candidate physiological ligands of MR positive APC in these organs.

Conclusions: The tissue and subcellular distribution of MR suggest it is appropriately located to serve as a high efficiency antigen uptake receptor of APC.

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References

Cochand L, Isler P, Songeon F, Nicod L . Human lung dendritic cells have an immature phenotype with efficient mannose receptors. Am J Respir Cell Mol Biol. 1999; 21(5):547-54. DOI: 10.1165/ajrcmb.21.5.3785. View

Linehan S, Martinez-Pomares L, Stahl P, Gordon S . Mannose receptor and its putative ligands in normal murine lymphoid and nonlymphoid organs: In situ expression of mannose receptor by selected macrophages, endothelial cells, perivascular microglia, and mesangial cells, but not dendritic cells. J Exp Med. 1999; 189(12):1961-72. PMC: 2192961. DOI: 10.1084/jem.189.12.1961. View

Apostolopoulos V, Barnes N, Pietersz G, McKenzie I . Ex vivo targeting of the macrophage mannose receptor generates anti-tumor CTL responses. Vaccine. 2000; 18(27):3174-84. DOI: 10.1016/s0264-410x(00)00090-6. View

Croizet K, Rabilloud R, Kostrouch Z, Nicolas J, Rousset B . Culture of dendritic cells from a nonlymphoid organ, the thyroid gland: evidence for TNFalpha-dependent phenotypic changes of thyroid-derived dendritic cells. Lab Invest. 2000; 80(8):1215-25. DOI: 10.1038/labinvest.3780129. View

Kato M, Neil T, Fearnley D, McLellan A, Vuckovic S, Hart D . Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. Int Immunol. 2000; 12(11):1511-9. DOI: 10.1093/intimm/12.11.1511. View

Mahnke K, Guo M, Lee S, Sepulveda H, Swain S, Nussenzweig M . The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol. 2000; 151(3):673-84. PMC: 2185598. DOI: 10.1083/jcb.151.3.673. View

van Egmond M, Damen C, van Spriel A, Vidarsson G, van Garderen E, van de Winkel J . IgA and the IgA Fc receptor. Trends Immunol. 2001; 22(4):205-11. DOI: 10.1016/s1471-4906(01)01873-7. View

Keler T, Ramakrishna V, Fanger M . Mannose receptor-targeted vaccines. Expert Opin Biol Ther. 2004; 4(12):1953-62. DOI: 10.1517/14712598.4.12.1953. View

Linehan S, Martinez-Pomares L, Silva R, Gordon S . Endogenous ligands of carbohydrate recognition domains of the mannose receptor in murine macrophages, endothelial cells and secretory cells; potential relevance to inflammation and immunity. Eur J Immunol. 2001; 31(6):1857-66. DOI: 10.1002/1521-4141(200106)31:6<1857::aid-immu1857>3.0.co;2-d. View

10.

Mellman I, Steinman R . Dendritic cells: specialized and regulated antigen processing machines. Cell. 2001; 106(3):255-8. DOI: 10.1016/s0092-8674(01)00449-4. View

11.

Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M . Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med. 2001; 194(6):769-79. PMC: 2195961. DOI: 10.1084/jem.194.6.769. View

12.

Croizet K, Rabilloud R, Nicolas J, Rousset B . Signaling from epithelial to dendritic cells of the thyroid gland: evidence for thyrocyte-derived factors controlling the survival, multiplication, and endocytic activity of dendritic cells. Lab Invest. 2001; 81(12):1601-13. DOI: 10.1038/labinvest.3780374. View

13.

Heystek H, Moulon C, Woltman A, Garonne P, van Kooten C . Human immature dendritic cells efficiently bind and take up secretory IgA without the induction of maturation. J Immunol. 2001; 168(1):102-7. DOI: 10.4049/jimmunol.168.1.102. View

14.

Steinman R, Nussenzweig M . Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A. 2002; 99(1):351-8. PMC: 117564. DOI: 10.1073/pnas.231606698. View

15.

Wollenberg A, Mommaas M, Oppel T, Schottdorf E, Gunther S, Moderer M . Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases. J Invest Dermatol. 2002; 118(2):327-34. DOI: 10.1046/j.0022-202x.2001.01665.x. View

16.

Thomson A, OConnell P, Steptoe R, Lu L . Immunobiology of liver dendritic cells. Immunol Cell Biol. 2002; 80(1):65-73. DOI: 10.1046/j.0818-9641.2001.01058.x. View

17.

Figdor C, van Kooyk Y, Adema G . C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol. 2002; 2(2):77-84. DOI: 10.1038/nri723. View

18.

Shortman K, Liu Y . Mouse and human dendritic cell subtypes. Nat Rev Immunol. 2002; 2(3):151-61. DOI: 10.1038/nri746. View

19.

Mahnke K, Schmitt E, Bonifaz L, Enk A, Jonuleit H . Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol. 2002; 80(5):477-83. DOI: 10.1046/j.1440-1711.2002.01115.x. View

20.

Deslee G, Charbonnier A, Hammad H, Angyalosi G, Tillie-Leblond I, Mantovani A . Involvement of the mannose receptor in the uptake of Der p 1, a major mite allergen, by human dendritic cells. J Allergy Clin Immunol. 2002; 110(5):763-70. DOI: 10.1067/mai.2002.129121. View