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Detection of Human Cytomegalovirus Genome and Gene Products in Central Nervous System Tumours

Overview
Journal Br J Cancer
Specialty Oncology
Date 2005 Feb 9
PMID 15700045
Citations 45
Authors
J Sabatier
E Uro-Coste
I Pommepuy
F Labrousse
S Allart
M Tremoulet
M B Delisle
P Brousset
Affiliations
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Abstract

Human cytomegalovirus (HCMV) genome and related proteins have been reported in a great proportion of malignant gliomas. However, these results are unexpected since HCMV is not known as an oncogenic virus. By immunohistochemistry (with an anti-IE1 monoclonal antibody) and in situ hybridisation (with biotinylated DNA probes) on tissue microarrays and frozen sections, we investigated a French series of central nervous system (CNS) tumours, including 97 glioblastomas. In 10 cases of glioblastoma, rare astrocyte-like cells, admixed with tumour cells, stained positively for HCMV and in one case a doubtful staining of rare cells was noticed. This may indicate a reactivation of the virus under local immunosuppression but none of the cases of CNS tumours (n=132) contained HCMV genomes and/or proteins in a significant proportion of tumour cells. Our results strongly suggest that HCMV is unlikely to be implicated in the development of human malignant gliomas, at least in French cases.

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