Responses of Müller Glia to Retinal Injury in Adult Zebrafish

Overview

Journal Vision Res

Specialty Ophthalmology

Date 2005 Feb 8

PMID 15695184

Citations 96

Authors

Patrick Yurco

David A Cameron

Affiliations

Soon will be listed here.

Abstract

In an effort to identify the cellular events that enable neuronal regeneration in the vertebrate retina, the identity and characteristics of mitotic and apoptotic cells were examined in lesioned retinas of adult zebrafish. Following lesion a complex spatiotemporal pattern of mitosis was observed, including a delayed entry of Müller glia into the cell cycle. Characteristics of these proliferative Müller glia indicated they might serve as a stem/precursor cell of regenerated retina. The results suggested a model of retinal regeneration in which lesions are filled, in part, by a localized en place cytogenesis within intact retina surrounding the lesion site.

Citing Articles

Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration.

Celotto L, Rost F, Machate A, Blasche J, Dahl A, Weber A Elife. 2023; 12.

PMID: 37988404 PMC: 10662954. DOI: 10.7554/eLife.86507.

Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina.

Emmerich K, White D, Kambhampati S, Casado G, Fu T, Chunawala Z Commun Biol. 2023; 6(1):534.

PMID: 37202450 PMC: 10193316. DOI: 10.1038/s42003-023-04898-9.

Assessing Rewiring of the Retinal Circuitry by Electroretinogram (ERG) After Inner Retinal Lesion in Adult Zebrafish.

Barrett L, Meighan P, Mitchell D, Varnum M, Stenkamp D Methods Mol Biol. 2023; 2636:421-435.

PMID: 36881314 DOI: 10.1007/978-1-0716-3012-9_23.

Generating Widespread and Scalable Retinal Lesions in Adult Zebrafish by Intraocular Injection of Ouabain.

Mitchell D, Stenkamp D Methods Mol Biol. 2023; 2636:221-235.

PMID: 36881303 DOI: 10.1007/978-1-0716-3012-9_12.

Cellular and subcellular optogenetic approaches towards neuroprotection and vision restoration.

Wood E, Kreymerman A, Kowal T, Buickians D, Sun Y, Muscat S Prog Retin Eye Res. 2022; 96:101153.

PMID: 36503723 PMC: 10247900. DOI: 10.1016/j.preteyeres.2022.101153.