Anti-inflammatory Strategies in Hypertension: Focus on COX-1 and COX-2

Overview

Journal Curr Hypertens Rep

Specialty Cardiology & Vascular Diseases

Date 2005 Feb 3

PMID 15683587

Citations 1

Authors

Matthias Hermann

Frank Enseleit

Frank T Ruschitzka

Affiliations

Soon will be listed here.

Abstract

An increasing body of evidence suggests that elevated levels of blood pressure may induce a proinflammatory response. Indeed, both C-reactive protein and blood pressure are independent determinants of cardiovascular risk, and, in combination, each parameter has additional predictive value. Hence, strategies targeted to lower blood pressure and reduce vascular inflammation may potentially provide clinical benefit. In this review, we discuss the role of chronic low-grade inflammation in the context of cardiovascular disease with a focus on roles of cyclooxygenase-1 and -2 in potential anti-inflammatory treatment strategies.

Citing Articles

Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease.

Dimitrijevic I, Edvinsson M, Chen Q, Malmsjo M, Kimblad P, Edvinsson L BMC Cardiovasc Disord. 2009; 9:40.

PMID: 19706169 PMC: 2744906. DOI: 10.1186/1471-2261-9-40.

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