Down's Syndrome in Western Australia: Cytogenetics and Incidence

Overview

Journal Hum Genet

Specialty Genetics

Date 1979 Apr 17

PMID 156692

Citations 7

Authors

M T Mulcahy

Affiliations

Soon will be listed here.

Abstract

235 cases of Down's syndrome were ascertained in a 10-year study of Down's syndrome in Western Australia. Although cytogenetic studies performed on 222 subjects confirmed that 95% of cases were trisomic due to nondisjunction, 4% were trisomic due to translocation, and 1% were mosaic, the ratio of inherited/sporadic translocations differed from that usually reported. Comparison of the results with those of an earlier Australian survey of Down's syndrome demonstrated a real fall in the incidence of Down's syndrome in Australia but no significant change in maternal age-specific incidences.

Citing Articles

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