Efavirenz Intoxication Due to Slow Hepatic Metabolism

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2005 Jan 26

PMID 15668854

Citations 18

Authors

B Hasse

H F Gunthard

G Bleiber

M Krause

Affiliations

Soon will be listed here.

Abstract

We describe a human immunodeficiency virus-positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for the CYP2B6 G516T allele, resulting in slow hepatic metabolism. After the dosage of efavirenz was lowered, all neuropsychiatric symptoms subsided.

Citing Articles

Beneficial and Adverse Effects of cART Affect Neurocognitive Function in HIV-1 Infection: Balancing Viral Suppression against Neuronal Stress and Injury.

Yuan N, Kaul M J Neuroimmune Pharmacol. 2019; 16(1):90-112.

PMID: 31385157 PMC: 7233291. DOI: 10.1007/s11481-019-09868-9.

Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives.

Storelli F, Samer C, Reny J, Desmeules J, Daali Y Clin Pharmacokinet. 2018; 57(10):1267-1293.

PMID: 29667038 DOI: 10.1007/s40262-018-0650-9.

A pharmacogenomic prospective randomized controlled trial of CYP2B6 polymorphisms and efavirenz dose adjustment among HIV-infected Thai patients: a pilot study.

Damronglerd P, Sukasem C, Thipmontree W, Puangpetch A, Kiertiburanakul S Pharmgenomics Pers Med. 2015; 8:155-62.

PMID: 26622191 PMC: 4638311. DOI: 10.2147/PGPM.S86446.

Association between efavirenz as initial therapy for HIV-1 infection and increased risk for suicidal ideation or attempted or completed suicide: an analysis of trial data.

Mollan K, Smurzynski M, Eron J, Daar E, Campbell T, Sax P Ann Intern Med. 2014; 161(1):1-10.

PMID: 24979445 PMC: 4204642. DOI: 10.7326/M14-0293.

Allele and genotype frequencies of CYP2B6 in a Turkish population.

Yuce-Artun N, Kose G, Suzen H Mol Biol Rep. 2014; 41(6):3891-6.

PMID: 24562623 DOI: 10.1007/s11033-014-3256-9.