Oral Cryotherapy for the Prevention of High-dose Melphalan-induced Stomatitis in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Overview

Journal Support Care Cancer

Specialties Critical Care
Oncology

Date 2005 Jan 26

PMID 15668755

Citations 23

Authors

Yoshinobu Aisa

Takehiko Mori

Masumi Kudo

Tomoko Yashima

Sakiko Kondo

Akihiro Yokoyama

Yasuo Ikeda

Shinichiro Okamoto

Affiliations

Soon will be listed here.

Abstract

Goals: The purpose of this study was to evaluate the efficacy of oral cryotherapy to prevent high-dose melphalan-induced stomatitis.

Patients And Methods: Eighteen consecutive recipients of allogeneic hematopoietic stem cell transplant conditioned with high-dose melphalan (140 mg/m2) in combination with fludarabine alone or with fludarabine and additional chemotherapy or radiation were enrolled. The severity of stomatitis was graded according to the National Cancer Institute Common Toxicity Criteria. Patients were kept on oral cryotherapy using ice chips and ice-cold water shortly before, during, and for additional 90 min after completion of melphalan administration.

Results: Only two of 18 patients (11.1%) developed grade 2 or 3 stomatitis while six of seven patients in the historical control developed it (85.7%; P=0.001).

Conclusion: These results suggested that oral cryotherapy could effectively prevent stomatitis caused by high-dose melphalan, and we recommend that it should be incorporated into the conditioning regimen with high-dose melphalan.

Citing Articles

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Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning.

Oku S, Futatsuki T, Imamura Y, Hikita H, Inada A, Mizutani S Support Care Cancer. 2023; 31(9):521.

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Al-Taie A, Al-Shohani A, Albasry Z, Altaee A J Pharm Bioallied Sci. 2020; 12(2):94-101.

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