An African American Family with Early-onset Alzheimer Disease and an APP (T714I) Mutation

Overview

Journal Neurology

Specialty Neurology

Date 2005 Jan 26

PMID 15668448

Citations 17

Authors

T Edwards-Lee

J M Ringman

J Chung

J Werner

A Morgan

P St George Hyslop

P Thompson

R Dutton

A Mlikotic

E Rogaeva

J Hardy

Affiliations

Soon will be listed here.

Abstract

The occurrence of an APP T174I mutation is described in a large American family of African descent with Alzheimer disease. The clinical characteristics were an unusually early onset of disease (early 30s), similar to a previously reported age at onset of this mutation in an Austrian family. Distinct from that family, seizures and myoclonus were prominent features of the disease in this kindred.

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