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PDGF Receptor Kinase Inhibitors for the Treatment of Restenosis

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Journal Cardiovasc Res
Date 2005 Jan 25
PMID 15664384
Citations 30
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Abstract

The clogging of arteries by neointima is a hallmark of atherosclerosis and of restenosis following balloon angioplasty. The realization in the 1980s that PDGF and its receptor play a key role in the onset of neointimal formation led us to develop PDGFR kinase inhibitors as antirestenosis agents. In this review, we describe the development of these inhibitors and their implementation as antirestenosis agents by localized delivery to the site of injury.

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