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Combined Chemical, Physical Hazards Make Exposures Harder to Calculate. Studies Show Multiple Exposures Must Be Evaluated Wholly Rather Than 'adding Up' Individual Risks

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Date 1994 Jun 1
PMID 15662858
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Abstract

Clearly, current research adds to the mounting scientific evidence that combined exposures can produce greater toxicity than would be predicted using an additive model. Although there is not yet a quantitative method to determine the risks associated with multiple exposures, safety and health specialists must begin to consider the health effects from the entire work process, rather than individual chemical or physical agents. Moreover, organizations involved in risk assessment and standard-setting must evaluate the interactive effects of combined chemical and physical agent exposures. This will make personnel exposure standards comprehensive in addressing realistic occupational health risks.