Reconstruction of Cellular Signalling Networks and Analysis of Their Properties

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2005 Jan 18

PMID 15654321

Citations 169

Authors

Jason A Papin

Tony Hunter

Bernhard O Palsson

Shankar Subramaniam

Affiliations

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Abstract

The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling.

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