» Articles » PMID: 15653826

Bacterial Contamination of Blood Components

Overview
Specialty Microbiology
Date 2005 Jan 18
PMID 15653826
Citations 88
Authors
Affiliations
Soon will be listed here.
Abstract

Blood for transfusion is a potential source of infection by a variety of known and unknown transmissible agents. Over the last 20 years, astounding reductions in the risk of viral infection via allogeneic blood have been achieved. As a result of this success, bacterial contamination of blood products has emerged as the greatest residual source of transfusion-transmitted disease. This paper summarizes the current status of detection, prevention, and elimination of bacteria in blood products for transfusion.

Citing Articles

Cold vs. Room Temperature: A Comparative Analysis of Platelet Functionality in Cold Storage.

Drossos P, Fortis S, Anastasiadi A, Pavlou E, Tsantes A, Spyratos G Biomedicines. 2025; 13(2).

PMID: 40002723 PMC: 11852762. DOI: 10.3390/biomedicines13020310.


Evaluation of bacterial safety approaches of platelet blood concentrates: bacterial screening and pathogen reduction.

Rezvany M, Hasan-Abad A, Sobhani-Nasab A, Esmaili M Front Med (Lausanne). 2024; 11:1325602.

PMID: 38651065 PMC: 11034438. DOI: 10.3389/fmed.2024.1325602.


Factors associated with increased risk of postoperative blood transfusion in patients undergoing total hip arthroplasty at an Irish University Hospital.

OConnor G, Mannion S, Purcell J Ir J Med Sci. 2024; 193(4):1971-1976.

PMID: 38472701 PMC: 11294405. DOI: 10.1007/s11845-024-03653-1.


Bacterial Contamination of Platelet Products.

Jacobs M, Zhou B, Tayal A, Maitta R Microorganisms. 2024; 12(2).

PMID: 38399662 PMC: 10891786. DOI: 10.3390/microorganisms12020258.


Verification of a method using magnetic bead enrichment and nucleic acid extraction to improve the molecular detection of bacterial contamination in blood components.

Na B, Lee J, Chang H, Park E, Park S, Lee J Microbiol Spectr. 2024; :e0276023.

PMID: 38319091 PMC: 10913752. DOI: 10.1128/spectrum.02760-23.


References
1.
Nikkari S, McLaughlin I, Bi W, Dodge D, Relman D . Does blood of healthy subjects contain bacterial ribosomal DNA?. J Clin Microbiol. 2001; 39(5):1956-9. PMC: 88056. DOI: 10.1128/JCM.39.5.1956-1959.2001. View

2.
Roth V, Arduino M, Nobiletti J, Holt S, Carson L, Wolf C . Transfusion-related sepsis due to Serratia liquefaciens in the United States. Transfusion. 2000; 40(8):931-5. DOI: 10.1046/j.1537-2995.2000.40080931.x. View

3.
Heltberg O, Skov F, Gerner-Smidt P, Kolmos H, DYBKJAER E, Gutschik E . Nosocomial epidemic of Serratia marcescens septicemia ascribed to contaminated blood transfusion bags. Transfusion. 1993; 33(3):221-7. DOI: 10.1046/j.1537-2995.1993.33393174448.x. View

4.
. Red blood cell transfusions contaminated with Yersinia enterocolitica--United States, 1991-1996, and initiation of a national study to detect bacteria-associated transfusion reactions. MMWR Morb Mortal Wkly Rep. 1997; 46(24):553-5. View

5.
. Update: Yersinia enterocolitica bacteremia and endotoxin shock associated with red blood cell transfusions--United States, 1991. MMWR Morb Mortal Wkly Rep. 1991; 40(11):176-8. View