CXC Chemokines: Angiogenesis, Immunoangiostasis, and Metastases in Lung Cancer

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2005 Jan 15

PMID 15650260

Citations 43

Authors

Robert M Strieter

John A Belperio

Marie D Burdick

Sherven Sharma

Steven M Dubinett

Michael P Keane

Affiliations

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Abstract

CXC chemokines have been found to be important in the regulation of angiogenesis and tumor-related immunity, and in promoting organ-specific metastases. This review highlights the importance of CXC chemokine ligands and receptors in mediating non-small cell lung cancer tumor-associated angiogenesis, "immunoangiostasis," and organ-specific metastases. These findings may ultimately lead to clinical strategies to target CXC chemokines in non-small cell lung cancer.

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