Neurological Channelopathies

Overview

Journal Postgrad Med J

Publisher Oxford University Press

Specialty General Medicine

Date 2005 Jan 11

PMID 15640425

Citations 18

Authors

T D Graves

M G Hanna

Affiliations

Soon will be listed here.

Abstract

Ion channels are membrane-bound proteins that perform key functions in virtually all human cells. Such channels are critically important for the normal function of the excitable tissues of the nervous system, such as muscle and brain. Until relatively recently it was considered that dysfunction of ion channels in the nervous system would be incompatible with life. However, an increasing number of human diseases associated with dysfunctional ion channels are now recognised. Such neurological channelopathies are frequently genetically determined but may also arise through autoimmune mechanisms. In this article clinical, genetic, immunological, and electrophysiological aspects of this expanding group of neurological disorders are reviewed. Clinical situations in which a neurological channelopathy should enter into the differential diagnosis are highlighted. Some practical guidance on how to investigate and treat this complex group of disorders is also included.

Citing Articles

A novel gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo.

Bernhard F, Schutte S, Heidenblut M, Oehme M, Rinne S, Decher N Front Cell Neurosci. 2024; 18:1441257.

PMID: 39416683 PMC: 11480015. DOI: 10.3389/fncel.2024.1441257.

Indelicato E, Boesch S Handb Exp Pharmacol. 2023; 279:227-248.

PMID: 36592223 DOI: 10.1007/164_2022_625.

Towards Zebrafish Models of CNS Channelopathies.

Kolesnikova T, Demin K, Costa F, Zabegalov K, de Abreu M, Gerasimova E Int J Mol Sci. 2022; 23(22).

PMID: 36430455 PMC: 9693542. DOI: 10.3390/ijms232213979.

Chronic inflammatory demyelinating polyradiculoneuropathy relapse after mexiletine withdrawal in a patient with concomitant myotonia congenita: A case report on a potential treatment option.

Portaro S, Biasini F, Bramanti P, Naro A, Calabro R Medicine (Baltimore). 2020; 99(28):e21117.

PMID: 32664137 PMC: 7360317. DOI: 10.1097/MD.0000000000021117.

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family.

Ranjan R, Logette E, Marani M, Herzog M, Tache V, Scantamburlo E Front Cell Neurosci. 2019; 13:358.

PMID: 31481875 PMC: 6710402. DOI: 10.3389/fncel.2019.00358.

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