[Cystic Pancreas Tumors and Their Classification: Features Old and New]

Overview

Journal Pathologe

Specialty Pathology

Date 2004 Dec 30

PMID 15624092

Citations 11

Authors

M Kosmahl

U Pauser

M Anlauf

B Sipos

K Peters

J Luttges

G Kloppel

Affiliations

Soon will be listed here.

Abstract

Cystic tumors and tumor-like lesions of the pancreas are rare, but have attracted a great deal of attention because they are easily recognized with new imaging methods and, in contrast to ductal adenocarcinoma, they can usually be cured surgically. The increasing resection rate in recent years has also increased our knowledge of cystic pancreatic tumors by conspicuously enlarging their morphological spectrum. Known entities have been better characterized (i.e. solid pseudopapillary neoplasm, intraductal papillary mucinous neoplasm) and new ones described (serous oligocystic adenoma, mucinous non-neoplastic cyst, acinar cell cystadenoma and cystic hamartoma). This review discusses the most important cystic tumors and tumor-like lesions, presents a new classification, and summarizes the immunohistochemical differential diagnosis.

Citing Articles

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References

Albores-Saavedra J . Acinar cystadenoma of the pancreas: a previously undescribed tumor. Ann Diagn Pathol. 2002; 6(2):113-5. DOI: 10.1053/adpa.2002.32379. View

George D, Murphy F, Michalski R, Ulmer B . Serous cystadenocarcinoma of the pancreas: a new entity?. Am J Surg Pathol. 1989; 13(1):61-6. DOI: 10.1097/00000478-198901000-00009. View

Wouters K, Ectors N, Van Steenbergen W, Aerts R, Driessen A, Van Hoe L . A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors. Virchows Arch. 1998; 432(2):187-9. DOI: 10.1007/s004280050154. View

Sessa F, Solcia E, Capella C, Bonato M, Scarpa A, Zamboni G . Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Arch. 1994; 425(4):357-67. DOI: 10.1007/BF00189573. View

Paal E, Thompson L, Heffess C . A clinicopathologic and immunohistochemical study of ten pancreatic lymphangiomas and a review of the literature. Cancer. 1998; 82(11):2150-8. DOI: 10.1002/(sici)1097-0142(19980601)82:11<2150::aid-cncr9>3.0.co;2-z. View

Wilentz R, Albores-Saavedra J, Zahurak M, Talamini M, Yeo C, Cameron J . Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol. 1999; 23(11):1320-7. DOI: 10.1097/00000478-199911000-00002. View

Kosmahl M, Egawa N, Schroder S, Carneiro F, Luttges J, Kloppel G . Mucinous nonneoplastic cyst of the pancreas: a novel nonneoplastic cystic change?. Mod Pathol. 2002; 15(2):154-8. DOI: 10.1038/modpathol.3880507. View

Hodgkinson D, REMINE W, Weiland L . A clinicopathologic study of 21 cases of pancreatic cystadenocarcinoma. Ann Surg. 1978; 188(5):679-84. PMC: 1396758. DOI: 10.1097/00000658-197811000-00017. View

Wilentz R, Albores-Saavedra J, Hruban R . Mucinous cystic neoplasms of the pancreas. Semin Diagn Pathol. 2000; 17(1):31-42. View

10.

Egawa N, Maillet B, Schroder S, Mukai K, Kloppel G . Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma. Virchows Arch. 1994; 424(1):13-7. DOI: 10.1007/BF00197387. View

11.

Rickaert F, Cremer M, Deviere J, Tavares L, LAMBILLIOTTE J, Schroder S . Intraductal mucin-hypersecreting neoplasms of the pancreas. A clinicopathologic study of eight patients. Gastroenterology. 1991; 101(2):512-9. DOI: 10.1016/0016-5085(91)90032-g. View

12.

Pappas S, Diaz L, Talamonti M . Pathologic quiz case: a cystic pancreatic mass discovered in a patient with ileocecal carcinoid. Arch Pathol Lab Med. 2002; 126(2):229-30. DOI: 10.5858/2002-126-0229-PQCACP. View

13.

Adsay N, Hasteh F, Cheng J, Bejarano P, Lauwers G, Batts K . Lymphoepithelial cysts of the pancreas: a report of 12 cases and a review of the literature. Mod Pathol. 2002; 15(5):492-501. DOI: 10.1038/modpathol.3880553. View

14.

Flaherty M, Benjamin D . Multicystic pancreatic hamartoma: a distinctive lesion with immunohistochemical and ultrastructural study. Hum Pathol. 1992; 23(11):1309-12. DOI: 10.1016/0046-8177(92)90301-i. View

15.

Luttges J, Feyerabend B, Buchelt T, Pacena M, Kloppel G . The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas. Am J Surg Pathol. 2002; 26(4):466-71. DOI: 10.1097/00000478-200204000-00008. View

16.

Compton C . Serous cystic tumors of the pancreas. Semin Diagn Pathol. 2000; 17(1):43-55. View

17.

Zamboni G, Scarpa A, Bogina G, Iacono C, Bassi C, Talamini G . Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol. 1999; 23(4):410-22. DOI: 10.1097/00000478-199904000-00005. View

18.

Zamboni G, Terris B, Scarpa A, Kosmahl M, Capelli P, Klimstra D . Acinar cell cystadenoma of the pancreas: a new entity?. Am J Surg Pathol. 2002; 26(6):698-704. DOI: 10.1097/00000478-200206000-00002. View

19.

Adsay N, Adair C, Heffess C, Klimstra D . Intraductal oncocytic papillary neoplasms of the pancreas. Am J Surg Pathol. 1996; 20(8):980-94. DOI: 10.1097/00000478-199608000-00007. View

20.

Kosmahl M, Pauser U, Peters K, Sipos B, Luttges J, Kremer B . Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal. Virchows Arch. 2004; 445(2):168-78. DOI: 10.1007/s00428-004-1043-z. View