Ethnic Difference of Helicobacter Pylori Gastritis: Korean and Japanese Gastritis is Characterized by Male- and Antrum-predominant Acute Foveolitis in Comparison with American Gastritis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2004 Dec 21

PMID 15609404

Citations 16

Authors

Inchul Lee

Hojung Lee

Mijung Kim

Manabu Fukumoto

Shinji Sawada

Shriram Jakate

Victor E Gould

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the clinicopathological factors underlying the ethnic differences of Helicobacter pylori gastritis and cancer.

Methods: We analyzed clinicopathological parameters of gastric biopsies having H pylori infection that were randomly selected from different ethnic populations including 147 Americans, 149 Japanese, and 181 Koreans.

Results: Males were predominant in Japanese and Korean populations (77.9 and 67.4% respectively) in comparison with Americans (48.3%) (P<0.001). H pylori gastritis in Koreans and Japanese was characterized by the predominant antral involvement. In the antrum, neutrophilic infiltration into the proliferative zone of pit, i.e. acute foveolitis, was more frequent in Koreans (82%) than in Japanese (71%) (P<0.05) and Americans (61%) (P<0.001). Interstitial neutrophilic infiltration, intestinal metaplasia and atrophy were also frequent in Koreans and Japanese. In the body, the prevalence of acute foveolitis was not significantly different among the populations while chronic interstitial inflammation and lymphoid follicles were more pronounced in the body of Americans than in the body of others (P<0.01).

Conclusion: The male-, and antrum-predominant H pylori gastritis in Koreans and Japanese is compatible with the pattern of sex and topographical distribution of gastric cancer incidence. Our data suggest that persistent acute foveolitis at the proliferative zone is a crucial step in the gastric carcinogenesis.

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References

Cohen S, Ellwein L . Cell proliferation in carcinogenesis. Science. 1990; 249(4972):1007-11. DOI: 10.1126/science.2204108. View

Jang J, Lee S, Jung Y, Song K, Fukumoto M, Gould V . Malgun (clear) cell change in Helicobacter pylori gastritis reflects epithelial genomic damage and repair. Am J Pathol. 2003; 162(4):1203-11. PMC: 1851220. DOI: 10.1016/S0002-9440(10)63916-8. View

Yu E, Lee H, Kim H, Lee M, Lee I . Acute inflammation of the proliferative zone of gastric mucosa in Helicobacter pylori gastritis. Pathol Res Pract. 1999; 195(10):689-97. DOI: 10.1016/S0344-0338(99)80060-0. View

Cerutti P . Prooxidant states and tumor promotion. Science. 1985; 227(4685):375-81. DOI: 10.1126/science.2981433. View

Lee H, Jang J, Kim Y, Ahn S, Gong M, Choi E . "Malgun" (clear) cell change of gastric epithelium in chronic Helicobacter pylori gastritis. Pathol Res Pract. 2000; 196(8):541-51. DOI: 10.1016/S0344-0338(00)80026-6. View

Nogueira C, Figueiredo C, Carneiro F, Gomes A, Barreira R, Figueira P . Helicobacter pylori genotypes may determine gastric histopathology. Am J Pathol. 2001; 158(2):647-54. PMC: 1850299. DOI: 10.1016/s0002-9440(10)64006-0. View

Asaka M, Kimura T, Kudo M, Takeda H, Mitani S, Miyazaki T . Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology. 1992; 102(3):760-6. DOI: 10.1016/0016-5085(92)90156-s. View

Tamir S, Tannenbaum S . The role of nitric oxide (NO.) in the carcinogenic process. Biochim Biophys Acta. 1996; 1288(2):F31-6. DOI: 10.1016/0304-419x(96)00021-2. View

Fuchs C, Mayer R . Gastric carcinoma. N Engl J Med. 1995; 333(1):32-41. DOI: 10.1056/NEJM199507063330107. View

10.

Graham D . Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model. Gastroenterology. 1997; 113(6):1983-91. DOI: 10.1016/s0016-5085(97)70019-2. View

11.

Genta R, Gurer I, Graham D . Geographical pathology of Helicobacter pylori infection: is there more than one gastritis?. Ann Med. 1995; 27(5):595-9. DOI: 10.3109/07853899509002475. View

12.

Dixon M, Genta R, Yardley J, Correa P . Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 1996; 20(10):1161-81. DOI: 10.1097/00000478-199610000-00001. View

13.

Kimura K, Sipponen P, Unge P, Ekstrom P, Satoh K, Hellblom M . Comparison of gastric histology among Swedish and Japanese patients with peptic ulcer and Helicobacter pylori infection. Scand J Gastroenterol. 2003; 38(5):491-7. View

14.

Correa P . A human model of gastric carcinogenesis. Cancer Res. 1988; 48(13):3554-60. View

15.

Chen X, van der Hulst R, Shi Y, Xiao S, Tytgat G, Ten Kate F . Comparison of precancerous conditions: atrophy and intestinal metaplasia in Helicobacter pylori gastritis among Chinese and Dutch patients. J Clin Pathol. 2001; 54(5):367-70. PMC: 1731420. DOI: 10.1136/jcp.54.5.367. View

16.

Bayerdorffer E, Lehn N, Hatz R, Mannes G, Oertel H, Sauerbruch T . Difference in expression of Helicobacter pylori gastritis in antrum and body. Gastroenterology. 1992; 102(5):1575-82. DOI: 10.1016/0016-5085(92)91716-h. View

17.

Feldman R, Eccersley A, Hardie J . Epidemiology of Helicobacter pylori: acquisition, transmission, population prevalence and disease-to-infection ratio. Br Med Bull. 1998; 54(1):39-53. DOI: 10.1093/oxfordjournals.bmb.a011678. View

18.

Dooley C, Cohen H, Fitzgibbons P, Bauer M, APPLEMAN M, Perez-Perez G . Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med. 1989; 321(23):1562-6. DOI: 10.1056/NEJM198912073212302. View

19.

Yamamoto S . Stomach cancer incidence in the world. Jpn J Clin Oncol. 2001; 31(9):471. DOI: 10.1093/jjco/31.9.471. View

20.

Correa P, Cuello C, Duque E, Burbano L, Garcia F, Bolanos O . Gastric cancer in Colombia. III. Natural history of precursor lesions. J Natl Cancer Inst. 1976; 57(5):1027-35. DOI: 10.1093/jnci/57.5.1027. View