Antimycobacterial Activity of a Series of Pyrazinoic Acid Esters

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 1992 Apr 3

PMID 1560435

Citations 24

Authors

M H Cynamon

S P Klemens

T S Chou

R H Gimi

J T Welch

Affiliations

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Abstract

A series of pyrazinoic acid esters has been prepared and evaluated for in vitro antimycobacterial activity. Several of the pyrazinoate esters have substantially better activity than the first-line antituberculous agent pyrazinamide against susceptible isolates of Mycobacterium turberculosis as well as activity against pyrazinamide-resistant isolates. The minimal inhibitory concentrations (MICs) were lower for each organism and at each pH than the MICs for pyrazinamide. The esters have activity against Mycobacterium bovis and Mycobacterium kansasii, two species resistant to pyrazinamide, but not against Mycobacterium avium complex.

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