Targeting the Mitogen-activated Protein Kinase Cascade to Treat Cancer

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2004 Dec 2

PMID 15573115

Citations 398

Authors

Judith S Sebolt-Leopold

Roman Herrera

Affiliations

Soon will be listed here.

Abstract

The RAS-mitogen activated protein kinase (MAPK) signalling pathway has long been viewed as an attractive pathway for anticancer therapies, based on its central role in regulating the growth and survival of cells from a broad spectrum of human tumours. Small-molecule inhibitors designed to target various steps of this pathway have entered clinical trials. What have we recently learned about their safety and effectiveness? Will the MAPK pathway prove amenable to therapeutic intervention?

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