Brain Tumor Classification by Proton MR Spectroscopy: Comparison of Diagnostic Accuracy at Short and Long TE

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2004 Dec 1

PMID 15569733

Citations 50

Authors

Carles Majos

Margarida Julia-Sape

Juli Alonso

Marta Serrallonga

Carles Aguilera

Juan J Acebes

Carles Arus

Jaume Gili

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Different TE can be used for obtaining MR spectra of brain tumors. The purpose of this study was to determine the influence of the TE used in brain tumor classification by comparing the performance of spectra obtained at two different TE (30 ms and 136 ms).

Methods: One hundred fifty-one studies of patients with brain tumors (37 meningiomas, 12 low grade astrocytomas, 16 anaplastic astrocytomas, 54 glioblastomas, and 32 metastases) were retrospectively selected from a series of 378 consecutive examinations of brain masses. Single voxel proton MR spectroscopy at TE 30 ms and 136 ms was performed with point-resolved spectroscopy in all cases. Fitted areas of nine resonances of interest were normalized to water. Tumors were classified into four groups (meningioma, low grade astrocytoma, anaplastic astrocytoma, and glioblastoma-metastases) by means of linear discriminant analysis. The performance of linear discriminant analysis at each TE was assessed by using the leave-one-out method.

Results: Tumor classification was slightly better at short TE (123 [81%] of 151 cases correctly classified) than at long TE (118 [78%] of 151 cases correctly classified). Meningioma was the only group that showed higher sensitivity and specificity at long TE. Improved results were obtained when both TE were considered simultaneously: the suggested diagnosis was correct in 105 (94%) of 112 cases when both TE agreed, whereas the correct diagnosis was suggested by at least one TE in 136 (90%) of 151 cases.

Conclusion: Short TE provides slightly better tumor classification, and results improve when both TE are considered simultaneously. Meningioma was the only tumor group in which long TE performed better than short TE.

Citing Articles

Proton MR spectroscopy shows improved performance to segregate high-grade astrocytoma subgroups when defined with the new 2021 World Health Organization classification of central nervous system tumors.

Majos C, Pons-Escoda A, Naval P, Guell A, Lucas A, Vidal N Eur Radiol. 2023; 34(4):2174-2182.

PMID: 37740778 DOI: 10.1007/s00330-023-10138-9.

Utility of 3T single-voxel proton MR spectroscopy for differentiating intracranial meningiomas from intracranial enhanced mass lesions.

Matsusue E, Inoue C, Tabuchi S, Yoshioka H, Nagao Y, Matsumoto K Acta Radiol Open. 2021; 10(4):20584601211009472.

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Robust Conditional Independence maps of single-voxel Magnetic Resonance Spectra to elucidate associations between brain tumours and metabolites.

Casana-Eslava R, Ortega-Martorell S, Lisboa P, Candiota A, Julia-Sape M, Martin-Guerrero J PLoS One. 2020; 15(7):e0235057.

PMID: 32609725 PMC: 7329095. DOI: 10.1371/journal.pone.0235057.

Accuracy of ADC derived from DWI for differentiating high-grade from low-grade gliomas: Systematic review and meta-analysis.

Wang Q, Lei D, Yuan Y, Xiong N Medicine (Baltimore). 2020; 99(8):e19254.

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Pons Escoda A, Naval Baudin P, Mora P, Cos M, Hernandez Ganan J, Narvaez J Insights Imaging. 2020; 11(1):23.

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