Plasma Leptin and Breast Cancer Risk: a Prospective Study in Northern Sweden

Overview

Journal Breast Cancer Res Treat

Specialty Oncology

Date 2004 Nov 30

PMID 15567935

Citations 37

Authors

Par Stattin

Stefan Soderberg

Carine Biessy

Per Lenner

Goran Hallmans

Rudolf Kaaks

Tommy Olsson

Affiliations

Soon will be listed here.

Abstract

Introduction: Obesity is associated with risk of breast cancer after menopause. Circulating levels of leptin are high in obesity and leptin stimulates growth of breast cancer cells.

Material And Methods: In a case-control study nested within the Northern Sweden Health and Disease Cohort, we measured leptin levels in prediagnostic plasma from 149 postmenopausal women who were diagnosed with breast cancer at a mean time 1.7 years (SD 2.0) after recruitment and among 258 control subjects.

Results: No significant association between plasma levels of leptin and breast cancer risk was observed. Odds ratios (ORs) of breast cancer with increasing levels of leptin were 1.00 [referent], 1.01 [95% CI = 0.58-1.84], 0.65 [0.36-1.18], and 0.94 [0.53-1.67], and (p(for trend) = 0.54). Adjustment for smoking, body mass index, and plasma insulin did not affect risk estimates.

Discussion: These data do not support the hypothesis that plasma leptin is a risk factor for breast cancer.

Citing Articles

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SERUM LEPTIN LEVEL IN BREAST CANCER.

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Association between circulating leptin concentration and gene polymorphism in patients with breast cancer: a meta-analysis.

Hao J, Zhang Q, Zhou Y, Chen L, Wu P Arch Med Sci. 2019; 15(2):275-283.

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Association of serum leptin with breast cancer: A meta-analysis.

Gu L, Wang C, Cao C, Cai L, Li D, Zheng Y Medicine (Baltimore). 2019; 98(5):e14094.

PMID: 30702563 PMC: 6380739. DOI: 10.1097/MD.0000000000014094.