Cancer Multidrug Resistance: a Review of Recent Drug Discovery Research

Overview

Journal IDrugs

Specialty Pharmacology

Date 2004 Nov 27

PMID 15565517

Citations 40

Authors

Mordechai Liscovitch

Yaakov Lavie

Affiliations

Soon will be listed here.

Abstract

Conventional cancer chemotherapy is seriously limited by tumor cells exhibiting multidrug resistance (MDR), caused by changes in the level or activity of membrane transporters that mediate energy-dependent drug efflux and of other proteins that affect drug metabolism and/or drug action. Many inhibitors of MDR transporters have been identified and some are undergoing clinical trials, but currently none are in clinical use. Here we briefly review the status of MDR drugs, outline novel approaches designed to suppress or circumvent MDR mechanisms and discuss the future of MDR therapy in oncology.

Citing Articles

The Blocking of Drug Resistance Channels by Selected Hydrophobic Statins in Chemoresistance Human Melanoma.

Placha W, Suder P, Panek A, Bronowicka-Adamska P, Zarzycka M, Szczygiel M Biomolecules. 2023; 13(12).

PMID: 38136555 PMC: 10741734. DOI: 10.3390/biom13121682.

Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology.

Chen Y, Yang L, Wang C, Wang C Oncol Lett. 2023; 26(6):502.

PMID: 37920438 PMC: 10618930. DOI: 10.3892/ol.2023.14089.

Docosahexaenoic Acid, a Key Compound for Enhancing Sensitization to Drug in Doxorubicin-Resistant MCF-7 Cell Line.

Crovella S, Ouhtit A, Rahman S, Rahman M Nutrients. 2023; 15(7).

PMID: 37049499 PMC: 10097357. DOI: 10.3390/nu15071658.

The Role of Genetic Pathways in the Development of Chemoradiation Resistance in Nasopharyngeal Carcinoma (NPC) Patients.

Mat Lazim N, Che Lah C, Juhari W, Sulong S, Zilfalil B, Abdullah B Genes (Basel). 2021; 12(11).

PMID: 34828441 PMC: 8619242. DOI: 10.3390/genes12111835.

Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study.

Sharmin S, Rahaman M, Martorell M, Sastre-Serra J, Sharifi-Rad J, Butnariu M Cancer Cell Int. 2021; 21(1):612.

PMID: 34801046 PMC: 8606078. DOI: 10.1186/s12935-021-02309-9.