A Transcriptional Profile of Aging in the Human Kidney

Overview

Journal PLoS Biol

Specialty Biology

Date 2004 Nov 25

PMID 15562319

Citations 165

Authors

Graham E J Rodwell

Rebecca Sonu

Jacob M Zahn

James Lund

Julie Wilhelmy

Lingli Wang

Wenzhong Xiao

Michael Mindrinos

Emily Crane

Eran Segal

Bryan D Myers

James D Brooks

Ronald W Davis

John Higgins

Art B Owen

Stuart K Kim

Affiliations

Soon will be listed here.

Abstract

In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age.

Citing Articles

Systemic inflammatory index as a predictive marker for the severity of coronary artery disease in individuals with chronic kidney disease.

Zhao M, Zhang Y, Huang X, Peng J J Geriatr Cardiol. 2024; 21(10):962-971.

PMID: 39619363 PMC: 11605509. DOI: 10.26599/1671-5411.2024.10.002.

Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance.

Garcia-Vilanova A, Allue-Guardia A, Chacon N, Akhter A, Singh D, Kaushal D Geroscience. 2024; 46(6):6395-6417.

PMID: 38969861 PMC: 11493886. DOI: 10.1007/s11357-024-01264-3.

voyAGEr, a free web interface for the analysis of age-related gene expression alterations in human tissues.

Schneider A, Martins-Silva R, Kaizeler A, Saraiva-Agostinho N, Barbosa-Morais N Elife. 2024; 12.

PMID: 38546191 PMC: 10977969. DOI: 10.7554/eLife.88623.

Kidney transplants from elderly donors: what we have learned 20 years after the Crystal City consensus criteria meeting.

Mella A, Calvetti R, Barreca A, Congiu G, Biancone L J Nephrol. 2024; 37(6):1449-1461.

PMID: 38446386 PMC: 11473582. DOI: 10.1007/s40620-024-01888-w.

Podocytes from hypertensive and obese mice acquire an inflammatory, senescent, and aged phenotype.

McKinzie S, Kaverina N, Schweickart R, Chaney C, Eng D, Pereira B Am J Physiol Renal Physiol. 2024; 326(4):F644-F660.

PMID: 38420674 PMC: 11208020. DOI: 10.1152/ajprenal.00417.2023.

References

Lee C, Weindruch R, Prolla T . Gene-expression profile of the ageing brain in mice. Nat Genet. 2000; 25(3):294-7. DOI: 10.1038/77046. View

Ly D, Lockhart D, Lerner R, Schultz P . Mitotic misregulation and human aging. Science. 2000; 287(5462):2486-92. DOI: 10.1126/science.287.5462.2486. View

Kirkwood T, Austad S . Why do we age?. Nature. 2000; 408(6809):233-8. DOI: 10.1038/35041682. View

Guarente L, Kenyon C . Genetic pathways that regulate ageing in model organisms. Nature. 2000; 408(6809):255-62. DOI: 10.1038/35041700. View

Zou S, Meadows S, Sharp L, Jan L, Jan Y . Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2000; 97(25):13726-31. PMC: 17643. DOI: 10.1073/pnas.260496697. View

Tissenbaum H, Guarente L . Model organisms as a guide to mammalian aging. Dev Cell. 2002; 2(1):9-19. DOI: 10.1016/s1534-5807(01)00098-3. View

Su A, Cooke M, Ching K, Hakak Y, Walker J, Wiltshire T . Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A. 2002; 99(7):4465-70. PMC: 123671. DOI: 10.1073/pnas.012025199. View

Pletcher S, Macdonald S, Marguerie R, Certa U, Stearns S, Goldstein D . Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol. 2002; 12(9):712-23. DOI: 10.1016/s0960-9822(02)00808-4. View

Yoshida S, Yashar B, Hiriyanna S, Swaroop A . Microarray analysis of gene expression in the aging human retina. Invest Ophthalmol Vis Sci. 2002; 43(8):2554-60. View

10.

Lund J, Tedesco P, Duke K, Wang J, Kim S, Johnson T . Transcriptional profile of aging in C. elegans. Curr Biol. 2002; 12(18):1566-73. DOI: 10.1016/s0960-9822(02)01146-6. View

11.

Higgins J, Shinghal R, Gill H, Reese J, Terris M, Cohen R . Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol. 2003; 162(3):925-32. PMC: 1868114. DOI: 10.1016/S0002-9440(10)63887-4. View

12.

Hekimi S, Guarente L . Genetics and the specificity of the aging process. Science. 2003; 299(5611):1351-4. DOI: 10.1126/science.1082358. View

13.

Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J . Aging and genome maintenance: lessons from the mouse?. Science. 2003; 299(5611):1355-9. DOI: 10.1126/science.1079161. View

14.

Kaul S, Yaguchi T, Taira K, Reddel R, Wadhwa R . Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res. 2003; 286(1):96-101. DOI: 10.1016/s0014-4827(03)00101-0. View

15.

Weindruch R . Caloric restriction, gene expression, and aging. Alzheimer Dis Assoc Disord. 2003; 17 Suppl 2:S58-9. DOI: 10.1097/00002093-200304002-00008. View

16.

Zhong S, Li C, Wong W . ChipInfo: Software for extracting gene annotation and gene ontology information for microarray analysis. Nucleic Acids Res. 2003; 31(13):3483-6. PMC: 169004. DOI: 10.1093/nar/gkg598. View

17.

Welle S, Brooks A, Delehanty J, Needler N, Thornton C . Gene expression profile of aging in human muscle. Physiol Genomics. 2003; 14(2):149-59. DOI: 10.1152/physiolgenomics.00049.2003. View

18.

Murphy C, McCarroll S, Bargmann C, Fraser A, Kamath R, Ahringer J . Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003; 424(6946):277-83. DOI: 10.1038/nature01789. View

19.

Hoang K, Tan J, Derby G, Blouch K, Masek M, Ma I . Determinants of glomerular hypofiltration in aging humans. Kidney Int. 2003; 64(4):1417-24. DOI: 10.1046/j.1523-1755.2003.00207.x. View

20.

Droge W . Oxidative stress and aging. Adv Exp Med Biol. 2004; 543:191-200. DOI: 10.1007/978-1-4419-8997-0_14. View