Immunoprevention and Immunotherapy of Cancer in Ageing

Overview

Journal Cancer Immunol Immunother

Specialties Allergy & Immunology
Oncology
Pharmacology

Date 2004 Nov 24

PMID 15558281

Citations 14

Authors

Mauro Provinciali

Arianna Smorlesi

Affiliations

Soon will be listed here.

Abstract

Over the last few years there has been a growing interest in geriatric oncology, mainly because of the evidence that advanced age is the greatest risk factor for the development of cancer and that, since the elderly population is rapidly expanding, so too will the number of cancer patients. This forecast necessitates the development of new and more specific strategies for the prevention and cure of cancer in the elderly and as a result an ever-increasing need for oncologists, geriatricians and researchers to work closely together. The increased incidence of cancer in elderly people has been related to the age-associated changes occurring in the immune system, the so-called immunosenescence. This phenomenon is best characterised by a remodelling of the immune system, which appears early on and progresses throughout a person's life and mainly involves a decrease in cellular functions. This review aims to provide a rationale for the development of specific immunotherapeutic and immunopreventive regimens for the elderly. We also include a discussion on the influence that immunosenescence has on the growth of tumours and the effectiveness of immunogene therapy and cancer vaccination following a brief analysis of the age-related alterations of the cell populations involved in antitumour immunity.

Citing Articles

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References

Zhou D, Chrest F, Adler W, Munster A, Winchurch R . Increased production of TGF-beta and Il-6 by aged spleen cells. Immunol Lett. 1993; 36(1):7-11. DOI: 10.1016/0165-2478(93)90061-6. View

Miller R . The aging immune system: primer and prospectus. Science. 1996; 273(5271):70-4. DOI: 10.1126/science.273.5271.70. View

Fabris N, Mocchegiani E, Provinciali M . Plasticity of neuroendocrine-thymus interactions during aging. Exp Gerontol. 1997; 32(4-5):415-29. DOI: 10.1016/s0531-5565(96)00166-0. View

Sadeghi H, Schnelle J, Thoma J, Nishanian P, Fahey J . Phenotypic and functional characteristics of circulating monocytes of elderly persons. Exp Gerontol. 2000; 34(8):959-70. DOI: 10.1016/s0531-5565(99)00065-0. View

Miller J, Allman D . The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J Immunol. 2003; 171(5):2326-30. DOI: 10.4049/jimmunol.171.5.2326. View

Walker P, Saas P, Dietrich P . Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back. J Immunol. 1997; 158(10):4521-4. View

Seymour K, Pettit S, OFlaherty E, Charnley R, Kirby J . Selection of metastatic tumour phenotypes by host immune systems. Lancet. 2000; 354(9194):1989-91. DOI: 10.1016/s0140-6736(99)04435-9. View

Dussault I, Miller S . Decline in natural killer cell-mediated immunosurveillance in aging mice--a consequence of reduced cell production and tumor binding capacity. Mech Ageing Dev. 1994; 75(2):115-29. DOI: 10.1016/0047-6374(94)90080-9. View

Dudley M, Wunderlich J, Robbins P, Yang J, Hwu P, Schwartzentruber D . Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 2002; 298(5594):850-4. PMC: 1764179. DOI: 10.1126/science.1076514. View

10.

Kishimoto S, Tomino S, Mitsuya H, Nishimura H . Age-related decrease in frequencies of B-cell precursors and specific helper T cells involved in the IgG anti-tetanus toxoid antibody production in humans. Clin Immunol Immunopathol. 1982; 25(1):1-10. DOI: 10.1016/0090-1229(82)90159-3. View

11.

Amici A, Smorlesi A, Noce G, Santoni G, Cappelletti P, Capparuccia L . DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Gene Ther. 2000; 7(8):703-6. DOI: 10.1038/sj.gt.3301151. View

12.

Rabinowich H, Goses Y, Reshef T, Klajman A . Interleukin-2 production and activity in aged humans. Mech Ageing Dev. 1985; 32(2-3):213-26. DOI: 10.1016/0047-6374(85)90081-8. View

13.

Angelis P, Scharf S, Christophidis N . Effects of age on neutrophil function and its relevance to bacterial infections in the elderly. J Clin Lab Immunol. 1997; 49(1):33-40. View

14.

Donnini A, Argentati K, Mancini R, Smorlesi A, Bartozzi B, Bernardini G . Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age. Exp Gerontol. 2002; 37(8-9):1097-112. DOI: 10.1016/s0531-5565(02)00087-6. View

15.

Chatta G, Andrews R, Rodger E, Schrag M, Hammond W, Dale D . Hematopoietic progenitors and aging: alterations in granulocytic precursors and responsiveness to recombinant human G-CSF, GM-CSF, and IL-3. J Gerontol. 1993; 48(5):M207-12. DOI: 10.1093/geronj/48.5.m207. View

16.

Wolters B, Junge U, Dziuba S, Roggendorf M . Immunogenicity of combined hepatitis A and B vaccine in elderly persons. Vaccine. 2003; 21(25-26):3623-8. DOI: 10.1016/s0264-410x(03)00399-2. View

17.

Antonaci S, Jirillo E, Ventura M, Garofalo A, BONOMO L . Non-specific immunity in aging: deficiency of monocyte and polymorphonuclear cell-mediated functions. Mech Ageing Dev. 1984; 24(3):367-75. DOI: 10.1016/0047-6374(84)90121-0. View

18.

Cavallo F, Giovarelli M, Gulino A, Vacca A, Stoppacciaro A, Modesti A . Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene. J Immunol. 1992; 149(11):3627-35. View

19.

Lollini P, Forni G . Cancer immunoprevention: tracking down persistent tumor antigens. Trends Immunol. 2003; 24(2):62-6. DOI: 10.1016/s1471-4906(02)00030-3. View

20.

Herrero C, Marques L, Lloberas J, Celada A . IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice. J Clin Invest. 2001; 107(4):485-93. PMC: 199261. DOI: 10.1172/JCI11696. View