MRNA Assessment for Procollagen Production in Women with Genuine Stress Urinary Incontinence

Overview

Journal Int Urogynecol J Pelvic Floor Dysfunct

Specialties Gynecology & Obstetrics
Urology

Date 2004 Nov 19

PMID 15549263

Citations 2

Authors

Panagiotis G Bakas

Angelos E Liapis

Irene Zervolea

Georgios Voutsinas

Demetrios Kletsas

Georgios Creatsas

Affiliations

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Abstract

The aim of the study was to examine changes in the levels of mRNA for procollagen type I and III in women with or without genuine stress incontinence (GSI). The study was performed in the 2nd Department of Obstetrics and Gynecology of University of Athens. Sixty-eight women participated in the study and they were divided in two groups. We did not find statistically significant difference between the two groups of patients in relation to the amount of mRNA of procollagen type I and III (p>0.05), but the quantity of collagen type I and III was significantly reduced in patients with stress incontinence (p<0.05). The possible cause for the reduction in the amount of collagen in women with GSI could be attributed to either a disturbance in the translation of mRNA to protein (collagen) or increased catabolism of collagen by its collagenase.

Citing Articles

Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies.

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IGF-1 regulates the growth of fibroblasts and extracellular matrix deposition in pelvic organ prolapse.

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