The Added Value of the Apparent Diffusion Coefficient Calculation to Magnetic Resonance Imaging in the Differentiation and Grading of Malignant Brain Tumors

Overview

Journal J Comput Assist Tomogr

Specialty Radiology

Date 2004 Nov 13

PMID 15538145

Citations 56

Authors

Nail Bulakbasi

Inanc Guvenc

Onder Onguru

Ersin Erdogan

Cem Tayfun

Taner Ucoz

Affiliations

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Abstract

Objective: ADC calculation can improve the diagnostic efficacy of MR imaging in brain tumor grading and differentiation.

Methods: Apparent diffusion coefficient (ADC) values and ratios of 33 low-grade (23 astrocytomas, 10 oligodendrogliomas) and 40 high-grade (25 metastases and 15 high-grade astrocytomas) malignant tumors were prospectively evaluated.

Results: Tumoral ADC values (r=-0.738, P <0.000) and ratios (r=-0.746, P < 0.000) were well correlated with higher degree of malignancy and quite effective in grading of malignant brain tumors (P < 0.000). By using cutoff values of 0.99 for tumoral ADC value and 1.22 for normalized ADC ratio, the sensitivity of MR imaging could be increased from 72.22% to 93.75% and 90.63%, the specificity from 81.08% to 92.68% and 90.24%, PPV from 78.79% to 90.91% and 87.88%, and NPV from 75.00% to 95.00% and 92.50%, respectively.

Conclusion: ADC calculation was quite effective in grading of malignant brain tumors but not in differentiation of them and added more information to conventional contrast-enhanced MR imaging.

Citing Articles

Correlation of ADC values of adult brain tumors with the diagnosis and pathological grade: A cross-sectional multicenter study.

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Histogram analysis of quantitative susceptibility mapping and apparent diffusion coefficient for identifying isocitrate dehydrogenase genotypes and tumor subtypes of adult-type diffuse gliomas.

Sun Y, Yang Z, Deng K, Geng Y, Hu X, Song Y Quant Imaging Med Surg. 2023; 13(12):8681-8693.

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Voxel-based clustered imaging by multiparameter diffusion tensor images for predicting the grade and proliferative activity of meningioma.

Takahashi Y, Oishi N, Yamao Y, Kunieda T, Kikuchi T, Fukuyama H Brain Behav. 2023; 13(10):e3201.

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Value of quantitative apparent diffusion coefficients in differentiating low-grade gliomas from mixed neuronal-glial tumors.

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