Effect of 50% Ethanolic Extract of Syzygium Aromaticum (L.) Merr. & Perry. (clove) on Sexual Behaviour of Normal Male Rats

Overview

Journal BMC Complement Altern Med

Publisher Biomed Central

Specialty Rehabilitation Medicine

Date 2004 Nov 9

PMID 15530165

Citations 33

Authors

Tajuddin

Shamshad Ahmad

Abdul Latif

Iqbal Ahmad Qasmi

Affiliations

Soon will be listed here.

Abstract

Background: The flower bud of Syzygium aromaticum (L.) Merr. & Perry. (clove) has been used in Unani medicine since ancient times for the treatment of male sexual disorders. The present study is aimed to investigate the effect of 50% ethanolic extract of clove on general mating behaviour, libido, potency along with its likely gastric ulceration and adverse effects on sexually normal male albino rats.

Methods: The suspension of the extract was administered orally at the dose of 100, 250, and 500 mg / kg, to different groups of male rats (n = 6) once a day for seven days. The female albino rats involved in mating were made receptive by hormonal treatment. The general mating behaviour, libido and potency were determined and compared with the standard reference drug sildenafil citrate. The probable gastric ulceration and adverse effects of the extract were also evaluated.

Results: Oral administration of the extract significantly increased the Mounting Frequency, Intromission Frequency; Intromission Latency, Erections; Quick Flips, Long Flips as well as aggregate of penile reflexes and caused significant reduction in the Mounting Latency and Post Ejaculatory Interval. The most appreciable effect of the extract was observed at the dose of 500 mg/kg. The test drug was also found to be devoid of any conspicuous gastric ulceration and adverse effects.

Conclusion: The results indicated that the 50% ethanolic extract of clove produced a significant and sustained increase in the sexual activity of normal male rats, without any conspicuous gastric ulceration and adverse effects. Thus, the resultant aphrodisiac effectivity of the extract lends support to the claims for its traditional usage in sexual disorders.

Citing Articles

Ameliorative action of eugenol on nitrate induced reproductive toxicity in male rats.

Rajini S, Sarjan H, Shivabasavaiah Toxicol Rep. 2024; 13:101702.

PMID: 39211010 PMC: 11357871. DOI: 10.1016/j.toxrep.2024.101702.

Omega 3 fatty acid improves sexual and erectile function in BPF-treated rats by upregulating NO/cGMP signaling and steroidogenic enzymes activities.

Odetayo A, Olayaki L Sci Rep. 2023; 13(1):18060.

PMID: 37872365 PMC: 10593954. DOI: 10.1038/s41598-023-45344-4.

Evaluating the Aphrodisiac Potential of L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats.

Rahman A, Alam F, Khan M, Sarfraz M, Basit A, Ahmad T Molecules. 2023; 28(17).

PMID: 37687143 PMC: 10489140. DOI: 10.3390/molecules28176314.

Anti-obesity effects of Camellia (Camellia oleifera Abel) oil treatment on high-fat diet-induced obesity in C57BL/6J mice.

Chilakala R, Moon H, Kim K, Yang S, Cheong S Phys Act Nutr. 2023; 27(2):50-61.

PMID: 37583072 PMC: 10440180. DOI: 10.20463/pan.2023.0018.

Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats.

Besong E, Akhigbe T, Ashonibare P, Oladipo A, Obimma J, Hamed M Redox Rep. 2023; 28(1):2225675.

PMID: 37345699 PMC: 10291914. DOI: 10.1080/13510002.2023.2225675.

References

Vasudevan K, Vembar S, Veeraraghavan K, Haranath P . Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats. Indian J Gastroenterol. 2000; 19(2):53-6. View

Ratnasooriya W, Dharmasiri M . Effects of Terminalia catappa seeds on sexual behaviour and fertility of male rats. Asian J Androl. 2001; 2(3):213-9. View

Ghelardini C, Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A . Local anaesthetic activity of beta-caryophyllene. Farmaco. 2001; 56(5-7):387-9. DOI: 10.1016/s0014-827x(01)01092-8. View

Damiani C, Rossoni L, Vassallo D . Vasorelaxant effects of eugenol on rat thoracic aorta. Vascul Pharmacol. 2003; 40(1):59-66. DOI: 10.1016/s1537-1891(02)00311-7. View

Criddle D, Madeira S, de Moura R . Endothelium-dependent and -independent vasodilator effects of eugenol in the rat mesenteric vascular bed. J Pharm Pharmacol. 2003; 55(3):359-65. DOI: 10.1211/002235702694. View

Miyazawa M, Hisama M . Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum). J Agric Food Chem. 2003; 51(22):6413-22. DOI: 10.1021/jf030247q. View

Tajuddin , Ahmad S, Latif A, Qasmi I . Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study. BMC Complement Altern Med. 2003; 3:6. PMC: 270058. DOI: 10.1186/1472-6882-3-6. View

Freireich E, Gehan E, Rall D, Schmidt L, Skipper H . Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep. 1966; 50(4):219-44. View

Cioli V, Silvestrini B, DORDONI F . Evaluation of the potential of gastric ulceration after administration of certain drugs. Exp Mol Pathol. 1967; 6(1):68-83. DOI: 10.1016/0014-4800(67)90006-8. View

10.

Dewsbury D, Davis Jr H . Effects of reserpine on the copulatory behavior of male rats. Physiol Behav. 1970; 5(11):1331-3. DOI: 10.1016/0031-9384(70)90050-8. View

11.

Hart B . Activation of sexual reflexes of male rats by dihydrotestosterone but not estrogen. Physiol Behav. 1979; 23(1):107-9. DOI: 10.1016/0031-9384(79)90129-x. View

12.

Szechtman H, Hershkowitz M, Simantov R . Sexual behavior decreases pain sensitivity and stimulated endogenous opioids in male rats. Eur J Pharmacol. 1981; 70(3):279-85. DOI: 10.1016/0014-2999(81)90161-8. View

13.

Srivastava K, Malhotra N . Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids. 1991; 42(1):73-81. DOI: 10.1016/0952-3278(91)90070-l. View

14.

Zheng G, Kenney P, Lam L . Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod. 1992; 55(7):999-1003. DOI: 10.1021/np50085a029. View

15.

Srivastava K . Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]. Prostaglandins Leukot Essent Fatty Acids. 1993; 48(5):363-72. DOI: 10.1016/0952-3278(93)90116-e. View

16.

Kurokawa M, Hozumi T, Basnet P, Nakano M, Kadota S, Namba T . Purification and characterization of eugeniin as an anti-herpesvirus compound from Geum japonicum and Syzygium aromaticum. J Pharmacol Exp Ther. 1998; 284(2):728-35. View

17.

Pourgholami M, Kamalinejad M, Javadi M, Majzoob S, Sayyah M . Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice. J Ethnopharmacol. 1999; 64(2):167-71. DOI: 10.1016/s0378-8741(98)00121-4. View