Occurrence of Extended-spectrum Beta-lactamases in Members of the Genus Shigella in the Republic of Korea

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2004 Nov 6

PMID 15528724

Citations 25

Authors

Seonghan Kim

Junyoung Kim

Yeonho Kang

YongKeun Park

Bokkwon Lee

Affiliations

Soon will be listed here.

Abstract

A nationwide survey was carried out in Korea to assess the prevalence of Shigella strains producing extended-spectrum beta-lactamases (ESBLs). From 1991 to 2002, 5,911 clinical strains were isolated and screened for resistance to extended-spectrum cephalosporins. Twenty of the Shigella isolates were ESBL positive, based on the synergistic effects between clavulanate and selected beta-lactams (ceftazidime and cefotaxime). Nucleotide sequence analysis of these isolates revealed that they harbored bla(TEM-19) (eight isolates), bla(TEM-15) (five isolates), bla(TEM-52) (six isolates), bla(TEM-17) (one isolate), bla(TEM-20) (one isolate), and bla(CTX-M-14) (three isolates). All the ESBL-encoding genes in this study were carried in conjugable plasmids. Thus, TEM-19, TEM-15, TEM-52, and CTX-M-14 beta-lactamases can be considered common Korean ESBL types in Shigella sonnei and are probably transmitted through interspecies spread between medical facilities and the community in Korea. This is the first report of the presence of TEM-17, TEM-19, and TEM-20 in Korea and in S. sonnei.

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References

Siu L, Lo J, Yuen K, Chau P, Ng M, Ho P . beta-lactamases in Shigella flexneri isolates from Hong Kong and Shanghai and a novel OXA-1-like beta-lactamase, OXA-30. Antimicrob Agents Chemother. 2000; 44(8):2034-8. PMC: 90010. DOI: 10.1128/AAC.44.8.2034-2038.2000. View

Oh J, Yu H, Kim S, Seol S, Cho D, Lee J . Changes in patterns of antimicrobial susceptibility and integron carriage among Shigella sonnei isolates from southwestern Korea during epidemic periods. J Clin Microbiol. 2003; 41(1):421-3. PMC: 149578. DOI: 10.1128/JCM.41.1.421-423.2003. View

Colom K, Perez J, Alonso R, Fernandez-Aranguiz A, Larino E, Cisterna R . Simple and reliable multiplex PCR assay for detection of blaTEM, bla(SHV) and blaOXA-1 genes in Enterobacteriaceae. FEMS Microbiol Lett. 2003; 223(2):147-51. DOI: 10.1016/S0378-1097(03)00306-9. View

Melano R, Corso A, Petroni A, Centron D, Orman B, Pereyra A . Multiple antibiotic-resistance mechanisms including a novel combination of extended-spectrum beta-lactamases in a Klebsiella pneumoniae clinical strain isolated in Argentina. J Antimicrob Chemother. 2003; 52(1):36-42. DOI: 10.1093/jac/dkg281. View

Mathew A, Harris A, Marshall M, Ross G . The use of analytical isoelectric focusing for detection and identification of beta-lactamases. J Gen Microbiol. 1975; 88(1):169-78. DOI: 10.1099/00221287-88-1-169. View

Southern E . Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975; 98(3):503-17. DOI: 10.1016/s0022-2836(75)80083-0. View

Shannon K, King A, Phillips I, Nicolas M, Philippon A . Importance of organisms producing broad-spectrum SHV-group beta-lactamases into the United Kingdom. J Antimicrob Chemother. 1990; 25(3):343-51. DOI: 10.1093/jac/25.3.343. View

Mabilat C, Courvalin P . Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae. Antimicrob Agents Chemother. 1990; 34(11):2210-6. PMC: 172024. DOI: 10.1128/AAC.34.11.2210. View

Ambler R, Coulson A, Frere J, Ghuysen J, Joris B, Forsman M . A standard numbering scheme for the class A beta-lactamases. Biochem J. 1991; 276 ( Pt 1):269-70. PMC: 1151176. DOI: 10.1042/bj2760269. View

10.

Jacoby G, Medeiros A . More extended-spectrum beta-lactamases. Antimicrob Agents Chemother. 1991; 35(9):1697-704. PMC: 245253. DOI: 10.1128/AAC.35.9.1697. View

11.

Jacoby G, Han P . Detection of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli. J Clin Microbiol. 1996; 34(4):908-11. PMC: 228915. DOI: 10.1128/jcm.34.4.908-911.1996. View

12.

Bush K, Jacoby G . Nomenclature of TEM beta-lactamases. J Antimicrob Chemother. 1997; 39(1):1-3. DOI: 10.1093/jac/39.1.1. View

13.

Gautom R . Rapid pulsed-field gel electrophoresis protocol for typing of Escherichia coli O157:H7 and other gram-negative organisms in 1 day. J Clin Microbiol. 1997; 35(11):2977-80. PMC: 230100. DOI: 10.1128/jcm.35.11.2977-2980.1997. View

14.

Poyart C, Mugnier P, Quesne G, Berche P, Trieu-Cuot P . A novel extended-spectrum TEM-type beta-lactamase (TEM-52) associated with decreased susceptibility to moxalactam in Klebsiella pneumoniae. Antimicrob Agents Chemother. 1998; 42(1):108-13. PMC: 105464. DOI: 10.1128/AAC.42.1.108. View

15.

Kim J, Kwon Y, Pai H, Kim J, Cho D . Survey of Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases: prevalence of SHV-12 and SHV-2a in Korea. J Clin Microbiol. 1998; 36(5):1446-9. PMC: 104851. DOI: 10.1128/JCM.36.5.1446-1449.1998. View

16.

Pai H, Lyu S, Lee J, Kim J, Kwon Y, Kim J . Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea. J Clin Microbiol. 1999; 37(6):1758-63. PMC: 84943. DOI: 10.1128/JCM.37.6.1758-1763.1999. View

17.

Ahamed J, Kundu M . Molecular characterization of the SHV-11 beta-lactamase of Shigella dysenteriae. Antimicrob Agents Chemother. 1999; 43(8):2081-3. PMC: 89421. DOI: 10.1128/AAC.43.8.2081. View

18.

Alamanos Y, Maipa V, Levidiotou S, Gessouli E . A community waterborne outbreak of gastro-enteritis attributed to Shigella sonnei. Epidemiol Infect. 2001; 125(3):499-503. PMC: 2869633. DOI: 10.1017/s0950268800004866. View

19.

Pai H, Choi E, Lee H, Hong J, Jacoby G . Identification of CTX-M-14 extended-spectrum beta-lactamase in clinical isolates of Shigella sonnei, Escherichia coli, and Klebsiella pneumoniae in Korea. J Clin Microbiol. 2001; 39(10):3747-9. PMC: 88424. DOI: 10.1128/JCM.39.10.3747-3749.2001. View

20.

Bradford P . Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev. 2001; 14(4):933-51, table of contents. PMC: 89009. DOI: 10.1128/CMR.14.4.933-951.2001. View