Intron-derived MicroRNAs--fine Tuning of Gene Functions

Overview

Journal Gene

Specialty Molecular Biology

Date 2004 Nov 6

PMID 15527961

Citations 37

Authors

Shao-Yao Ying

Shi-Lung Lin

Affiliations

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Abstract

New evidence suggests that abundant small RNAs, microRNAs (miRNAs) act as regulatory vehicles to repress translation or cleave RNA transcripts, depending on their complementarity to the target gene, and result in modulation of gene expression. This review describes that the miRNAs derived from introns can suppress intracellular RNA homologues and regulate the gene function.

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