The RAF Proteins Take Centre Stage

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2004 Nov 3

PMID 15520807

Citations 494

Authors

Claudia Wellbrock

Maria Karasarides

Richard Marais

Affiliations

Soon will be listed here.

Abstract

Since their discovery over 20 years ago, the RAF proteins have been intensely studied. For most of that time, the focus of the field has been the C-RAF isoform and its role as an effector of the RAS proteins. However, a report that implicates B-RAF in human cancer has highlighted the importance of all members of this protein kinase family and recent studies have uncovered intriguing new data relating to their complex regulation and biological functions.

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