Effectiveness of Haemophilus Influenzae Type B Vaccination Against Bacterial Pneumonia in Colombia

Overview

Journal Vaccine

Specialty Allergy & Immunology

Date 2004 Nov 3

PMID 15519705

Citations 10

Authors

Fernando De la Hoz

Ana Betty Higuera

Jose Luis Di Fabio

Mauricio Luna

Alberto Gomez Naranjo

Maria de la Luz Valencia

Desiree Pastor

Andrew J Hall

Affiliations

Soon will be listed here.

Abstract

Aims: To assess the effectiveness of a Hib vaccination program against X-ray defined bacterial pneumonia in children <2 years in Colombia.

Methods: 389 cases of radiologically confirmed pneumonia were recruited from hospitals in Bogota and Medellin, Colombia. Two controls per case, matched on age, sex, and socio-economic level, were selected from children attending child health services at the hospitals where pneumonia cases were admitted.

Results: The risk of having X-ray confirmed pneumonia decreased with each Hib dose received; the vaccine effectiveness was 47% (2-72%) among those receiving one dose; 52% for two doses received, and 55% for three doses. These effectiveness levels remained after adjusting for other factors associated with risk of pneumonia.

Conclusions: This study indicates that trials may have underestimated the proportion of radiological pneumonia in the under 2s that is due to Hib. This suggests that the impact of the vaccination will be greater than expected if it can be extended to reach the poorest children, who are at the greatest risk.

Citing Articles

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Using Standardized Interpretation of Chest Radiographs to Identify Adults with Bacterial Pneumonia--Guatemala, 2007-2012.

Wortham J, Gray J, Verani J, Contreras C, Bernart C, Moscoso F PLoS One. 2015; 10(7):e0133257.

PMID: 26207918 PMC: 4514878. DOI: 10.1371/journal.pone.0133257.

Early indication for a reduced burden of radiologically confirmed pneumonia in children following the introduction of routine vaccination against Haemophilus influenzae type b in Nha Trang, Vietnam.

Flasche S, Takahashi K, Vu D, Suzuki M, Nguyen T, Le H Vaccine. 2014; 32(51):6963-6970.

PMID: 25444823 PMC: 7125610. DOI: 10.1016/j.vaccine.2014.10.055.