[Panzytopenia from Combination Therapy with Azathioprin and Allopurinol]
Overview
Overview
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Azathioprine has been used in rheumatology for more than twenty years. Indications are collagen diseases with multiorgan involvement, where co-medications are frequently necessary. We describe a patient suffering from pancytopenia following a combination therapy of azathioprine and allopurinol because of lupus erythematodes and diabetic nephropathy with hyperuricemia.
References
1.
Chan G, Erdmann G, Gruber S, Matas A, Canafax D
. Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients. J Clin Pharmacol. 1990; 30(4):358-63.
DOI: 10.1002/j.1552-4604.1990.tb03606.x.
View
2.
Weinshilboum R
. Methylation pharmacogenetics: thiopurine methyltransferase as a model system. Xenobiotica. 1992; 22(9-10):1055-71.
DOI: 10.3109/00498259209051860.
View
3.
Sandborn W
. Azathioprine: state of the art in inflammatory bowel disease. Scand J Gastroenterol Suppl. 1998; 225:92-9.
DOI: 10.1080/003655298750027290.
View
4.
Stockhausen G, Hopf U, GLOGNER P
. [Pancytopenia following a combination therapy with allopurinol and azathioprine. Discussion contribution and conclusion]. Med Welt. 1977; 28(4):198.
View
5.
Kennedy D, Hayney M, Lake K
. Azathioprine and allopurinol: the price of an avoidable drug interaction. Ann Pharmacother. 1996; 30(9):951-4.
DOI: 10.1177/106002809603000906.
View