Type of Wine and Risk of Lung Cancer: a Case-control Study in Spain

Overview

Journal Thorax

Date 2004 Nov 2

PMID 15516476

Citations 11

Authors

A Ruano-Ravina

A Figueiras

J M Barros-Dios

Affiliations

Soon will be listed here.

Abstract

Background: Few epidemiological studies have examined the effect of wine on the risk of lung cancer. A study was therefore undertaken to estimate the effect of wine consumption, both overall and by type of wine, on the risk of developing lung cancer.

Methods: A hospital based case-control study was conducted on 319 subjects (132 cases, 187 controls) in 1999-2000. All subjects were interviewed about their lifestyles with particular reference to alcohol consumption and tobacco use. The results were analysed using non-parametric logistic regression. The main outcome measure was the risk of lung cancer associated with consumption of wine and its individual types.

Results: A very slight but significant association was observed between the risk of lung cancer and white wine consumption (odds ratio (OR) 1.20 for each daily glass). Red wine consumption, on the other hand, had an OR of 0.43 (95% CI 0.19 to 0.96), with each daily glass of red wine having an inverse association with the development of lung cancer (OR 0.87 (95% CI 0.77 to 0.99)). There was no apparent association between lung cancer and consumption of beer or spirits.

Conclusions: These results suggest that the consumption of red wine is negatively associated with the development of lung cancer. Further studies are needed to test this finding in cancer induced laboratory animals.

Citing Articles

Consumption of Red Versus White Wine and Cancer Risk: A Meta-Analysis of Observational Studies.

Lim R, Rhee J, Hoang M, Qureshi A, Cho E Nutrients. 2025; 17(3).

PMID: 39940392 PMC: 11820282. DOI: 10.3390/nu17030534.

Etiology of lung cancer: Evidence from epidemiologic studies.

Zou K, Sun P, Huang H, Zhuo H, Qie R, Xie Y J Natl Cancer Cent. 2024; 2(4):216-225.

PMID: 39036545 PMC: 11256564. DOI: 10.1016/j.jncc.2022.09.004.

[Research Progress of the Effect of Mediterranean Diet on the Correlation of Lung Cancer].

Gao M, Lai K, Lu Z, Liu Y, Li N, Geng Q Zhongguo Fei Ai Za Zhi. 2024; 27(4):299-305.

PMID: 38769833 PMC: 11110241. DOI: 10.3779/j.issn.1009-3419.2024.106.09.

Long-Term Health Outcomes of Regular, Moderate Red Wine Consumption.

Wojtowicz J Cureus. 2023; 15(10):e46786.

PMID: 37954791 PMC: 10634232. DOI: 10.7759/cureus.46786.

Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States.

Rivera A, Nan H, Li T, Qureshi A, Cho E Cancer Epidemiol Biomarkers Prev. 2016; 25(12):1550-1558.

PMID: 27909090 PMC: 5137801. DOI: 10.1158/1055-9965.EPI-16-0303.

References

Ruano-Ravina A, Figueiras A, Barreiro-Carracedo M, Barros-Dios J . Occupation and smoking as risk factors for lung cancer: a population-based case-control study. Am J Ind Med. 2003; 43(2):149-55. DOI: 10.1002/ajim.10171. View

Woodson K, Albanes D, Tangrea J, Rautalahti M, Virtamo J, Taylor P . Association between alcohol and lung cancer in the alpha-tocopherol, beta-carotene cancer prevention study in Finland. Cancer Causes Control. 1999; 10(3):219-26. DOI: 10.1023/a:1008911624785. View

Freudenheim J, Ram M, Nie J, Muti P, Trevisan M, Shields P . Lung cancer in humans is not associated with lifetime total alcohol consumption or with genetic variation in alcohol dehydrogenase 3 (ADH3). J Nutr. 2003; 133(11):3619-24. DOI: 10.1093/jn/133.11.3619. View

Mannisto S, Smith-Warner S, Spiegelman D, Albanes D, Anderson K, van den Brandt P . Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiol Biomarkers Prev. 2004; 13(1):40-8. DOI: 10.1158/1055-9965.epi-038-3. View

Bandera E, Freudenheim J, Graham S, Marshall J, Haughey B, Swanson M . Alcohol consumption and lung cancer in white males. Cancer Causes Control. 1992; 3(4):361-9. DOI: 10.1007/BF00146890. View

De Stefani E, Correa P, Fierro L, Fontham E, Chen V, Zavala D . The effect of alcohol on the risk of lung cancer in Uruguay. Cancer Epidemiol Biomarkers Prev. 1993; 2(1):21-6. View

Potter J, Sellers T, Folsom A, McGovern P . Alcohol, beer, and lung cancer in postmenopausal women. The Iowa Women's Health Study. Ann Epidemiol. 1992; 2(5):587-95. DOI: 10.1016/1047-2797(92)90003-9. View

Parkin D, Pisani P, Lopez A, Masuyer E . At least one in seven cases of cancer is caused by smoking. Global estimates for 1985. Int J Cancer. 1994; 59(4):494-504. DOI: 10.1002/ijc.2910590411. View

Ziegler R, Mayne S, Swanson C . Nutrition and lung cancer. Cancer Causes Control. 1996; 7(1):157-77. DOI: 10.1007/BF00115646. View

10.

Jang M, Cai L, Udeani G, Slowing K, Thomas C, Beecher C . Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997; 275(5297):218-20. DOI: 10.1126/science.275.5297.218. View

11.

Brenner H, Blettner M . Controlling for continuous confounders in epidemiologic research. Epidemiology. 1997; 8(4):429-34. View

12.

Knekt P, Jarvinen R, Seppanen R, Hellovaara M, Teppo L, Pukkala E . Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol. 1997; 146(3):223-30. DOI: 10.1093/oxfordjournals.aje.a009257. View

13.

Bandera E, Freudenheim J, Marshall J, Zielezny M, Priore R, Brasure J . Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States). Cancer Causes Control. 1998; 8(6):828-40. DOI: 10.1023/a:1018456127018. View

14.

Ahrendt S, Chow J, Yang S, Wu L, Zhang M, Jen J . Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer. Cancer Res. 2000; 60(12):3155-9. View

15.

Mollerup S, Ovrebo S, Haugen A . Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells. Int J Cancer. 2001; 92(1):18-25. View

16.

Zang E, Wynder E . Reevaluation of the confounding effect of cigarette smoking on the relationship between alcohol use and lung cancer risk, with larynx cancer used as a positive control. Prev Med. 2001; 32(4):359-70. DOI: 10.1006/pmed.2000.0818. View

17.

Figueiras A, Cadarso-Suarez C . Application of nonparametric models for calculating odds ratios and their confidence intervals for continuous exposures. Am J Epidemiol. 2001; 154(3):264-75. DOI: 10.1093/aje/154.3.264. View

18.

Bandera E, Freudenheim J, Vena J . Alcohol consumption and lung cancer: a review of the epidemiologic evidence. Cancer Epidemiol Biomarkers Prev. 2001; 10(8):813-21. View

19.

Boffetta P, Ye W, Adami H, Mucci L, Nyren O . Risk of cancers of the lung, head and neck in patients hospitalized for alcoholism in Sweden. Br J Cancer. 2001; 85(5):678-82. PMC: 2364115. DOI: 10.1054/bjoc.2001.1986. View

20.

Rachtan J . Alcoholic beverages consumption and lung cancer cell types among women in Poland. Lung Cancer. 2002; 35(2):119-27. DOI: 10.1016/s0169-5002(01)00331-2. View