Familial Barrett's Esophagus Associated with Adenocarcinoma

Overview

Journal Gastroenterology

Specialty Gastroenterology

Date 1992 Apr 1

PMID 1551547

Citations 29

Authors

V J Jochem

P A Fuerst

J J Fromkes

Affiliations

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Abstract

A family with six cases of Barrett's esophagus over three generations is described. The Barrett's esophagus affected only males, and there were three associated adenocarcinomas. The mechanism of inheritance is compatible with an autosomal dominant pattern with nearly complete penetrance. Other case reports in the literature are compared with this familial case of Barrett's esophagus with associated adenocarcinomas.

Citing Articles

Barrett's esophagus: results from an Italian cohort with tight endoscopic surveillance.

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Systematic review with meta-analysis: the effects of family history on the risk of Barrett's oesophagus and oesophageal adenocarcinoma.

Peters Y, van Grinsven E, Siersema P Aliment Pharmacol Ther. 2021; 54(7):868-879.

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Germline variant in MSX1 identified in a Dutch family with clustering of Barrett's esophagus and esophageal adenocarcinoma.

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The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.

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Sun X, Elston R, Falk G, Grady W, Faulx A, Mittal S Mol Genet Genomic Med. 2016; 4(4):407-19.

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